Age-related changes in brain structural covariance networks.
Age-related changes in brain structural covariance networks.
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大脑结构协方差网络与年龄相关的变化
DOI：
10.3389/fnhum.2013.00098
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发表时间：
2013
影响因子：
2.9
通讯作者：
Li D
中科院分区：
文献类型：
--
作者：
Li X;Pu F;Fan Y;Niu H;Li S;Li D
以前的神经影像学研究表明，正常衰老过程中大脑的变化不仅仅表现为区域性改变，而是表现为皮层连接模式的重组。使用基于体素的形态测量学的结构协方差网络（SCN）的调查是一种先进的方法来研究人类皮层不同区域之间的灰质（GM）体积的协方差模式。到目前为止，在正常老化过程中关键SCN的组织如何变化仍然是未知的。在这项研究中，我们使用SCN映射方法调查了240名年龄在18-89岁之间的健康参与者的8个大规模网络。这些参与者被细分为年轻（18-23岁），中年（30-58岁）和老年（61-89岁）受试者。从广泛报道的功能性内在连接网络中选择八个种子区域。显示出与这些种子区域显著正相关的体素被用来描述SCN的拓扑组织。所有这些网络在其空间范围内表现出与正常衰老相关的非线性模式。这些网络，除了主要的运动网络，有一个分布式的拓扑结构在年轻的参与者，一个急剧本地化的拓扑结构在中年参与者，并在老年参与者相对稳定。使用初级运动皮层得出的结构协方差仅限于年轻和老年参与者的同侧运动区域，但包括中年参与者的对侧同源区域。此外，在与语言相关的语音和语义处理，执行控制和默认模式网络（DMN）相关的结构网络中，组间存在显着差异。综上所述，本研究的结果证明了SCN拓扑组织中与年龄相关的变化，并为人类大脑的正常衰老提供了见解。
Previous neuroimaging studies have suggested that cerebral changes over normal aging are not simply characterized by regional alterations, but rather by the reorganization of cortical connectivity patterns. The investigation of structural covariance networks (SCNs) using voxel-based morphometry is an advanced approach to examining the pattern of covariance in gray matter (GM) volumes among different regions of the human cortex. To date, how the organization of critical SCNs change during normal aging remains largely unknown. In this study, we used an SCN mapping approach to investigate eight large-scale networks in 240 healthy participants aged 18–89 years. These participants were subdivided into young (18–23 years), middle aged (30–58 years), and older (61–89 years) subjects. Eight seed regions were chosen from widely reported functional intrinsic connectivity networks. The voxels showing significant positive associations with these seed regions were used to describe the topological organization of an SCN. All of these networks exhibited non-linear patterns in their spatial extent that were associated with normal aging. These networks, except the primary motor network, had a distributed topology in young participants, a sharply localized topology in middle aged participants, and were relatively stable in older participants. The structural covariance derived using the primary motor cortex was limited to the ipsilateral motor regions in the young and older participants, but included contralateral homologous regions in the middle aged participants. In addition, there were significant between-group differences in the structural networks associated with language-related speech and semantics processing, executive control, and the default-mode network (DMN). Taken together, the results of this study demonstrate age-related changes in the topological organization of SCNs, and provide insights into normal aging of the human brain.
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影响因子：
3.7
作者：
Chao, LL;Weisberg, J;Martin, A
通讯作者：
Martin, A
影响因子：
3.7
作者：
Federmeier, KD;Van Petten, C;Kutas, M
通讯作者：
Kutas, M
DOI：
10.1523/jneurosci.2308-09.2009
发表时间：
2009-12-16
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Gong G;Rosa-Neto P;Carbonell F;Chen ZJ;He Y;Evans AC
通讯作者：
Evans AC
影响因子：
9.9
作者：
Bakkour, Akram;Morris, John C.;Dickerson, Bradford C.
通讯作者：
Dickerson, Bradford C.
探索人类大脑功能的科学
DOI：
10.1073/pnas.0911855107
发表时间：
2010-03-09
影响因子：
11.1
作者：
Biswal, Bharat B.;Mennes, Maarten;Milham, Michael P.
通讯作者：
Milham, Michael P.