The Effects of Hyponatraemia and Subarachnoid Haemorrhage on the Cerebral Vasomotor Responses of the Rabbit
The Effects of Hyponatraemia and Subarachnoid Haemorrhage on the Cerebral Vasomotor Responses of the Rabbit
复制标题
低钠血症和蛛网膜下腔出血对家兔脑血管舒缩反应的影响
DOI：
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发表时间：
1991
影响因子：
6.3
通讯作者：
J. Pickard
中科院分区：
文献类型：
--
作者：
R. Nelson;S. Perry;A. Burns;J. Roberts;J. Pickard
脑自身调节功能受损和低钠血症的发生均与蛛网膜下腔出血（SAH）后迟发性脑缺血和梗死的发病机制有关，但其病理生理学和相互作用尚未完全了解。本文研究了低钠血症和蛛网膜下腔出血对家兔脑血管反应的影响。在正常和低钠血症家兔脑池内两次注射自体血产生实验性SAH之前和之后6天，测定脑血管对高碳酸血症的反应性和对曲美他芬诱导的低血压的脑自动调节。通过给予去氨加压素和腹膜内5%葡萄糖，在48小时内逐渐诱导低钠血症（平均血浆钠为119 mM）。假手术动物接受生理盐水。脑血管反应性（皮质CBF/mm Hg PaCO 2的%变化±SD，通过氢清除率测量）（4.8 ± 3.0%）和SAH（1.3 ± 2.0%）动物显著低于（p < 0.05），而低钠血症-SAH动物的反应性被保留（9.8 ± 6.0%）。低钠血症和SAH单独均显著损害CBF自动调节，但其联合作用不具有累加性。全身性低钠血症损害正常的脑血管反应，但不增加兔实验性SAH的影响。
Impairment of cerebral autoregulation and development of hyponatraemia are both implicated in the pathogenesis of delayed cerebral ischaemia and infarction following subarachnoid haemorrhage (SAH) but the pathophysiology and interactions involved are not fully understood. We have studied the effects of hyponatraemia and SAH on the cerebral vasomotor responses of the rabbit. Cerebrovascular reactivity to hypercapnia and cerebral autoregulation to trimetaphan-induced hypotension were determined in normal and hyponatraemic rabbits before and 6 days after experimental SAH produced by two intracisternal injections of autologous blood. Hyponatraemia (mean plasma sodium of 119 mM) was induced gradually over 48 h by administration of Desmopressin and intraperitoneal 5% dextrose. Sham animals received normal saline. The cerebrovascular reactivity (% change ±SD in cortical CBF/mm Hg PaCO2, measured by hydrogen clearance) of hyponatraemic (4.8 ± 3.0%) and SAH (1.3 ± 2.0%) animals was significantly less (p < 0.05) than control (11.6 ± 4.0%) and sham (8 ± 2.0%) animals, whereas the reactivity of hyponatraemic-SAH animals was preserved (9.8 ± 6.0%). Hyponatraemia and SAH alone each significantly impaired CBF autoregulation but their combined effects were not additive. Systemic hyponatraemia impairs normal cerebral vasomotor responses but does not augment the effects of experimental SAH in the rabbit.
抗利尿激素分泌异常综合征患者的血浆心房钠尿激素水平。
DOI：
10.1210/jcem-67-3-571
发表时间：
1988
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
Manoogian,C;Pandian,M;Ehrlich,L;Fisher,D;Horton,R
通讯作者：
Horton,R