Familial mediterranean fever medicated with an herbal medicine in Japan
Familial mediterranean fever medicated with an herbal medicine in Japan
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日本使用草药治疗家族性地中海热
DOI：
10.1111/j.1328-0867.2004.01831.x
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发表时间：
2004
影响因子：
1.4
通讯作者：
G. Takada
中科院分区：
文献类型：
--
作者：
M. Komatsu;Tsutomu Takahashi;N. Uemura;G. Takada
家族性地中海热（FMF）是一种常染色体隐性遗传病，由FMF基因（MEFV）基因突变引起，以自限性周期性发热和血清炎为特征，常伴有肾淀粉样变性。秋水仙碱能有效治疗FMF的炎症发作。如果服用秋水仙碱，90%以上的FMF患者发作完全缓解或明显改善。然而，秋水仙碱的副作用应引起注意。我们在此报告一个罕见的日本FMF病例，其中草药“ShoSaiko-To （TJ-9）”对预防发作有效。此外，我们报道E148Q是日本人MEFV基因的一个正常变体，而E148Q是FMF的一个共同始创突变。
Familial mediterranean fever (FMF) is an autosomal recessive disorder resulting from the genetic mutations in the FMF gene ( MEFV ) and characterized by self-limited periodic fever and serositis, often associated with renal amyloidosis. The inflammatory attacks of FMF can be effectively treated with colchicine. More than 90% of FMF patients have a complete remission or a marked amelioration of attacks if they take the colchicine. 1 However, attention should be paid to the side-effects of colchicine use. We report here a rare Japanese case of FMF where an herbal medicine, ‘ShoSaiko-To (TJ-9)’, was effective for prophylaxis of the attacks. In addition, we report that the E148Q, which was reported as a common founder mutation for FMF, is a normal variant of the MEFV gene among Japanese.