Lower circulating endocannabinoid levels in children with autism spectrum disorder
Lower circulating endocannabinoid levels in children with autism spectrum disorder
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DOI：
10.1186/s13229-019-0256-6
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发表时间：
2019-01-30
期刊：
影响因子：
6.2
通讯作者：
Tam, Joseph
中科院分区：
文献类型：
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作者：
Aran, Adi;Eylon, Maya;Tam, Joseph
背景内源性大麻素系统（endocannabinoid system，ECS）是突触可塑性和神经调节的主要调节器。ECS的改变已经在自闭症谱系障碍（ASD）的几种动物模型中得到证实。在其中一些模型中，激活ECS拯救了社会赤字。在人类ASD的ECS失调的证据正在出现，但全面的评估和与疾病特征的相关性还没有报道。花生四烯酸（AA）、N-棕榈酰乙醇胺（PEA）和N-油酰乙醇胺（OEA），通过液相色谱/串联质谱法分析了93名ASD儿童（年龄=13.14.1，范围6-21; 79%男孩）和93名年龄和性别匹配的神经典型儿童（年龄=11.84.3，范围5.5-21; 79%男孩）。结果与性别和药物使用相关，并与年龄，BMI和ASD参与者的适应功能相关，如自闭症诊断观察表（ADOS-2），Vineland适应行为量表-II（VABS-II）和社会反应量表-II（SRS-2）的评分所反映的。（pmol/mL，平均值+/- SEM）（0.722 +/- 0.045 vs. 1.252 +/- 0.072，P
BackgroundThe endocannabinoid system (ECS) is a major regulator of synaptic plasticity and neuromodulation. Alterations of the ECS have been demonstrated in several animal models of autism spectrum disorder (ASD). In some of these models, activating the ECS rescued the social deficits. Evidence for dysregulations of the ECS in human ASD are emerging, but comprehensive assessments and correlations with disease characteristics have not been reported yet.MethodsSerum levels of the main endocannabinoids, N-arachidonoylethanolamine (AEA or anandamide) and 2-arachidonoylglycerol (2-AG), and their related endogenous compounds, arachidonic acid (AA), N-palmitoylethanolamine (PEA), and N-oleoylethanolamine (OEA), were analyzed by liquid chromatography/tandem mass spectrometry in 93 children with ASD (age=13.14.1, range 6-21; 79% boys) and 93 age- and gender-matched neurotypical children (age=11.84.3, range 5.5-21; 79% boys). Results were associated with gender and use of medications, and were correlated with age, BMI, and adaptive functioning of ASD participants as reflected by scores of Autism Diagnostic Observation Schedule (ADOS-2), Vineland Adaptive Behavior Scale-II (VABS-II), and Social Responsiveness Scale-II (SRS-2).ResultsChildren with ASD had lower levels (pmol/mL, mean +/- SEM) of AEA (0.722 +/- 0.045 vs. 1.252 +/- 0.072, P