Synovial inflammation and osteoarthritis progression: Effects of nonsteroidal antiinflammatory drugs
Synovial inflammation and osteoarthritis progression: Effects of nonsteroidal antiinflammatory drugs
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DOI：
10.1053/joca.1998.0179
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发表时间：
1999-05-01
影响因子：
7
通讯作者：
Doherty, M
中科院分区：
文献类型：
--
作者：
Doherty, M
骨关节炎（OA）是滑膜关节固有的缓慢修复过程（图1）。对任何关节部位的各种损伤都可能引发OA，所有关节组织都参与反应。在大多数情况下，OA会补偿这种侮辱。在少数情况下，由于严重的损伤或修复不良，关节失代偿，进展为进一步的损伤，并增加与症状和残疾的关联。值得强调的是：观察到的临床表现和结果的显著异质性是意料之中的。发展的危险因素可能与进展的危险因素不同。不同关节组织的相对重要性，就开始部位和组织反应的比例而言，可能因个体和关节部位而异。根据风险因素、发病机制、治疗反应和结果，从一个OA部位推断到另一个OA部位是有问题的。
OSTEOARTHRITIS (OA) is the inherent, slow repair process of synovial joints (Fig. 1). Diverse insults to any joint component may trigger OA, and all joint tissues take part in the response. In most cases, OA compensates for the insult. In a minority, either due to overwhelming insult or to poor repair, the joint decompensates, progressing to further damage and increasing association with symptoms and disability. The following are worthy of emphasis:The observed marked heterogeneity in clinical presentation and outcome is to be expected Risk factors for development may di# er from risk factors for progression The relative importance of di# erent joint tissues, in terms of site of initiation and in proportional tissue response, may vary between individuals and between joint sites. Extrapolation from one OA site to another is problematic for risk factors, pathogenesis, treatment response and outcome.