A randomized trial of visual attention of preterm infants fed docosahexaenoic acid until nine months.
A randomized trial of visual attention of preterm infants fed docosahexaenoic acid until nine months.
复制标题
一项针对早产儿视觉注意力的随机试验，他们喂食二十二碳六烯酸直至九个月。
作者：
Werkman,SH;Carlson,SE
这项随机、双盲试验验证了一个假设，即在市售的含≥3%亚麻酸（18∶3n− 3）的早产儿和足月婴儿配方奶粉中添加0.2%的二十二碳六烯酸（DHA，22∶6n− 3），可以增强早产儿的新奇偏好和视觉注意力。在我们中心照顾的早产儿中，研究婴儿是被认为发育迟缓风险较低的一组。研究婴儿从平均出生后25天开始接受指定的饮食（对照，补充DHA），直至9个月。在6.5，9和12个月过去的任期，他们进行了测试的视觉识别记忆（新奇偏好）和注意力与费根测试婴儿智力。采用重复测量方差分析法分析补充DHA的效果。在对新奇刺激和熟悉刺激的配对比较中，补充DHA的婴儿和对照组婴儿具有相同的新奇偏好，但补充DHA的婴儿对新奇刺激（P<0.03）和熟悉刺激（P<0.02）的注视更加离散，总体注视时间更短（P<0.03）。这些数据与n−3缺乏和n−3喂养的猴子的数据类似，因为DHA状态较好的那组猴子的整体注视时间较短。由于较短的注视时间与更快的信息处理有关，因此喂食仅含亚麻酸配方奶粉的早产儿的信息处理速度可能比喂食DHA的早产儿慢。
This randomized, double‐blind trial tested the hypothesis that the addition of 0.2% docosahexaenoic acid (DHA, 22∶6n−3) from marine oil to commercially‐available preterm and term formulas with ≥3% linolenic acid (18∶3n−3) would enhance novelty preference and visual attention of preterm infants. Among preterm infants cared for in our center, study infants were a select group considered to be at lower risk for developmental delay. Study infants received their assigned diet (control, DHA‐supplemented) from a mean postnatal age of 25 d until 9 mon past term. At 6.5, 9, and 12 mon past term, they were tested for visual recognition memory (novelty preference) and attention with the Fagan Test of Infant Intelligence. The effects of DHA supplementation were analyzed by repeated measures analysis of variance. In paired comparisons of novel and familiar stimuli, DHA‐supplemented and control infants had the same novelty preference, but supplemented infants had more discrete looks to both novel (P<0.03) and familiar (P<0.02) stimuli and a shorter overall look duration (P<0.03). These data are analogous to those from n−3‐deficient and n−3‐fed monkeys in that the group with better DHA status had shorter overall look duration. Because shorter look duration has been associated with more rapid information processing, preterm infants fed formulas with only linolenic acid may have had slower information processing than those fed DHA.