Relation Between Oppositional/Conduct Behaviors and Executive Function Among Youth with Histories of Heavy Prenatal Alcohol Exposure
Relation Between Oppositional/Conduct Behaviors and Executive Function Among Youth with Histories of Heavy Prenatal Alcohol Exposure
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DOI：
10.1111/acer.14036
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发表时间：
2019-06-01
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影响因子：
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通讯作者：
Mattson, Sarah N.
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作者：
Doyle, Lauren R.;Glass, Leila;Mattson, Sarah N.
背景 产前大量接触酒精的青少年有较高的行为问题和精神病理学发生率，包括增加的对抗和行为行为。这些担忧与执行功能 (EF) 缺陷之间的关系尚不清楚。我们调查了青少年的逆反行为和行为行为与 EF 之间的关系，以便为有针对性的干预提供信息。方法 年龄 10 至 17 岁的受试者 (N = 267) 分为 3 组：暴露于酒精但有对抗/行为行为 (AE+)、暴露于酒精而无对抗/行为 (AE-) 和对照组 (CON)。通过多变量协方差分析，然后进行单变量方差分析和成对比较，对直接神经心理学（Delis-Kaplan 执行功能系统 [D-KEFS]）和间接家长报告（执行功能行为评定量表 [BRIEF]）EF 测量的组间差异进行测试。在二次分析中评估了 AE 组中注意力缺陷/多动障碍 (ADHD) 的影响。结果在D-KEFS上，存在群体综合主效应，6个变量中的3个具有显着主效应（CON>AE+，AE-）。在 AE 组中，ADHD 并没有改变结果。在BRIEF上，群体有一个综合显着的主效应，在所有尺度上都有显着的主效应（CON
Background Youth with heavy prenatal alcohol exposure have high rates of behavioral concerns and psychopathology, including increased oppositional and conduct behaviors. The relation between those concerns and executive function (EF) deficits is unknown. We investigated the association of oppositional and conduct behavior and EF in adolescents to inform targeted intervention. Methods Subjects (N = 267) ages 10 to 17 years comprised 3 groups: alcohol-exposed with oppositional/conduct behaviors (AE+), alcohol-exposed without oppositional/conduct behaviors (AE-), and controls (CON). Group differences on direct neuropsychological (Delis-Kaplan Executive Function System [D-KEFS]) and indirect parent-report (Behavior Rating Inventory of Executive Function [BRIEF]) EF measures were tested with multivariate analysis of covariances, followed by univariate analysis of variances and pairwise comparisons. The contribution of attention-deficit/hyperactivity disorder (ADHD) within the AE groups was assessed in secondary analyses. Results On the D-KEFS, there was an omnibus main effect of group, with significant main effects on 3 of 6 variables (CON>AE+, AE-). Within the AE groups, ADHD did not alter the results. On the BRIEF, there was an omnibus significant main effect of group, with significant main effects on all scales (CON