The efficacy of artemisinin, artemether, and lumefantrine against Babesia gibsoni in vitro
The efficacy of artemisinin, artemether, and lumefantrine against Babesia gibsoni in vitro
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DOI：
10.1016/j.parint.2014.12.006
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发表时间：
2015-04-01
影响因子：
1.9
通讯作者：
Hikasa, Yoshiaki
中科院分区：
文献类型：
--
作者：
Iguchi, Aiko;Matsuu, Aya;Hikasa, Yoshiaki
青蒿素有许多衍生物，它对疟原虫有效。然而，只有有限数量的报道证实了青蒿素衍生物对Babyspp的功效。本研究通过体外实验研究了青蒿素和蒿甲醚对吉氏巴此外，蒿甲醚和本芴醇之间的相互作用进行了评价。这些药物抑制了B的生长。gibsoni，但青蒿素和蒿甲醚对阿托伐醌抗性B的敏感性较低。gibsoni比对野生型B。吉布森尼。蒿甲醚与本芴醇相互作用对B有协同作用。吉布森尼。虽然还需要进一步的研究，但青蒿素衍生物的组合可能对巴贝虫病有用。(C)2014爱思唯尔爱尔兰有限公司版权所有。
Artemisinin has many derivatives, and it is effective against Plasmodium spp. However, only a limited number of reports have confirmed the efficacy of artemisinin derivatives against Babesia spp. In this study, whether artemisinin and artemether could inhibit the growth of Babesia gibsoni was evaluated in vitro. In addition, the interaction between artemether and lumefantrine was evaluated. These drugs inhibited the growth of B. gibsoni, but artemisinin and artemether showed lower sensitivity against atovaquone-resistant B. gibsoni than against wild-type B. gibsoni. The interaction between artemether and lumefantrine showed synergism against B. gibsoni. Although further study is needed, the combination of artemisinin derivatives could be useful for babesiosis. (C) 2014 Elsevier Ireland Ltd. All rights reserved.