Resistance exercise interventions during and following cancer treatment: a systematic review.
Resistance exercise interventions during and following cancer treatment: a systematic review.
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DOI：
10.12788/j.suponc.0002
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发表时间：
2013-06
期刊：
影响因子：
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通讯作者：
B. Focht;S. Clinton;S. Devor;M. Garver;Alexander R. Lucas;J. Thomas-Ahner;E. Grainger
中科院分区：
文献类型：
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作者：
B. Focht;S. Clinton;S. Devor;M. Garver;Alexander R. Lucas;J. Thomas-Ahner;E. Grainger
来自先前系统性综述的结果表明，在癌症治疗期间和之后，运动导致许多临床相关生理和生活质量（QOL）结局的有意义的改善。然而，大多数运动-癌症研究都集中在有氧运动（AE）的益处上，而抗阻运动（RE）单独作为癌症患者和幸存者的支持性护理干预措施的疗效知识仍然有限。因此，本综述的目的是提供第一个系统评价RE单独对癌症治疗期间和之后的临床相关生理和QOL结果的影响。进行文献检索，以确定研究癌症患者和幸存者的RE干预。提取了生理学（健康、身体功能和身体成分）和QOL（疲劳、心理健康和癌症特异性和整体QOL结果）数据。科恩的d效应量计算每个结果。共有15项研究（6项在接受积极癌症治疗的样本中，9项在完成癌症治疗的样本中）涉及1，077名参与者，符合入选标准。结果显示，平均而言，RE导致肌肉力量的大效应量改善（d = 0.86），身体功能的中等效应量改善（d = 0.66），身体成分（d = 0.28）和QOL（d = 0.25）结局的小效应量改善。RE后观察到的效应量与先前对运动-癌症文献（主要关注AE）进行的全面综述中报告的运动干预的效应量相当。此外，这些研究的方法学质量一般都很高。总体而言，本系统性综述的结果表明，RE是一种有前途的支持性护理干预，可在癌症治疗期间和之后显著改善临床相关生理和QOL结局。
Findings from prior systematic reviews suggest that exercise results in meaningful improvements in many clinically relevant physiologic and quality of life (QOL) outcomes during and following cancer treatment. However, the majority of exercise-cancer studies have focused upon the benefits of aerobic exercise (AE) and knowledge of the efficacy of resistance exercise (RE) alone as a supportive care intervention for cancer patients and survivors remains limited. Consequently, the purpose of this review was to provide the first systematic evaluation of the effects of RE alone upon clinically relevant physiologic and QOL outcomes during and following cancer treatment. Literature searches were conducted to identify studies examining RE interventions in cancer patients and survivors. Data were extracted on physiologic (fitness, physical function, and body composition) and QOL (fatigue, psychological well-being, and cancer-specific and global QOL outcomes. Cohen's d effect sizes were calculated for each outcome. A total of 15 studies (6 in samples undergoing active cancer treatment and 9 in samples having completed cancer treatment) involving 1,077 participants met the inclusion criteria. Findings revealed that, on average, RE resulted in large effect-size improvements in muscular strength (d = 0.86), moderate effect-size improvements in physical function (d = 0.66), and small effect-size improvements in body composition (d = 0.28) and QOL (d = 0.25) outcomes. The effect sizes observed following RE are comparable in magnitude to the effects of exercise interventions reported in prior comprehensive reviews of the exercise-cancer literature which primarily focused upon AE. Additionally, the methodologic quality of the studies was generally strong. Taken collectively, results of this systematic review suggest that RE is a promising supportive care intervention that results in meaningful improvements in clinically relevant physiologic and QOL outcomes during and following cancer treatment.