Receptive-field modification in rat visual cortex induced by paired visual stimulation and single-cell spiking
Receptive-field modification in rat visual cortex induced by paired visual stimulation and single-cell spiking
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DOI：
10.1016/j.neuron.2005.12.009
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发表时间：
2006-01-19
期刊：
影响因子：
16.2
通讯作者：
Dan, Y
中科院分区：
文献类型：
--
作者：
Meliza, CD;Dan, Y
视皮层感受野（receptive fields，RFs）的经验依赖性可塑性涉及潜在神经回路中的突触修饰，但这些修饰的位点和机制仍有待阐明。使用在体全细胞记录，我们表明，配对视觉刺激在一个给定的视网膜位置与尖峰的单个神经元在发育中的大鼠视觉皮层诱导快速RF修改。在配对的RF位置处对视觉刺激的响应的时间过程被改变，其中响应的增强在尖峰时间之前并且响应的减小在尖峰之后。这种双向修饰与尖峰时间依赖的可塑性是一致的。响应修改也发生在附近的位置，其方向和幅度与配对位置的变化相关。此外，在不成对的位置的变化显示出负相关的初始强度的响应，这可能有助于快速修改的空间RF配置文件。
Experience-dependent plasticity of visual cortical receptive fields (RFs) involves synaptic modifications in the underlying neural circuits, but the site and mechanism of these modifications remain to be elucidated. Using in vivo whole-cell recordings, we show that pairing visual stimulation at a given retinal location with spiking of a single neuron in developing rat visual cortex induces rapid RF modifications. The time course of the response to the visual stimulus at the paired RF location is altered, with an enhancement of the response preceding the spike time and a reduction following the spike. Such bidirectional modification is consistent with spike timing-dependent plasticity. Response modification also occurs at nearby locations, the direction and magnitude of which are correlated with the change at the paired location. In addition, changes at unpaired locations show a negative correlation with the initial strength of the response, which may facilitate rapid modification of the spatial RF profile.