Role of nonexercise activity thermogenesis in resistance to fat gain in humans
Role of nonexercise activity thermogenesis in resistance to fat gain in humans
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DOI：
10.1126/science.283.5399.212
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发表时间：
1999-01-08
期刊：
影响因子：
56.9
通讯作者：
Jensen, MD
中科院分区：
文献类型：
--
作者：
Levine, JA;Eberhardt, NL;Jensen, MD
人类对暴饮暴食引起的体重增加的敏感度在个体间表现出相当大的差异。通过测量16名非肥胖志愿者的能量储存和消耗的变化来研究这种变化的生理基础，这些志愿者每天摄入的能量超过维持体重所需的1000千卡，每天总能量消耗增加的三分之二是由于与坐立不安、保持姿势和其他日常生活体力活动相关的非运动活动产热(NEAT)的增加。NEAT的变化解释了脂肪储存的10倍差异，并直接预测了对过度喂养的脂肪增加的抵抗(相关系数=0.77%，概率为0.001)。这些结果表明，当人类吃得过多时，激活NEAT会驱散多余的能量以保持苗条，而如果不激活NEAT，可能会导致随时增加脂肪。
Humans show considerable interindividual variation in susceptibility to weight gain in response to overeating. The physiological basis of this variation was investigated by measuring changes in energy storage and expenditure in 16 nonobese volunteers who were fed 1000 kilocalories per day in excess of weight-maintenance requirements for 8 weeks, Two-thirds of the increases in total daily energy expenditure was due to increased nonexercise activity thermogenesis (NEAT), which is associated with fidgeting, maintenance of posture, and other physical activities of daily life. Changes in NEAT accounted for the 10-fold differences in fat storage that occurred and directly predicted resistance to fat gain with overfeeding (correlation coefficient = 0.77, probability < 0.001). These results suggest that as humans overeat, activation of NEAT dissipates excess energy to preserve Leanness and that failure to activate NEAT may result in ready fat gain.