Male-specific volume expansion of the human hippocampus during adolescence
Male-specific volume expansion of the human hippocampus during adolescence
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DOI：
10.1093/cercor/bhh121
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发表时间：
2005-02-01
期刊：
影响因子：
3.7
通讯作者：
Kurachi, M
中科院分区：
文献类型：
--
作者：
Suzuki, M;Hagino, H;Kurachi, M
为了阐明青春期期间大脑发育的变化，使用基于体素的形态测量（VBM）和磁共振成像（MRI）的体积感兴趣区域（ROI）分析，比较了健康的年轻青少年和老年青少年受试者的大脑形态。对 23 名（10 名男性和 13 名女性）年轻青少年受试者（13-14 岁）和 30 名（15 名男性和 15 名女性）老年青少年受试者（19-21 岁）进行了高分辨率三维 MRI 扫描。 VBM 的全脑分析显示，老年青少年受试者的左侧内侧颞区灰质明显多于年轻青少年受试者，而左侧内侧额叶区（布罗德曼 6 区）的灰质明显较少。在体积分析中，与年轻青少年相比，老年青少年的大脑灰质体积显着减少，而大脑白质体积显着增加。男性老年青少年的海马体体积明显大于男性年轻青少年。年轻和年长青少年受试者的海马旁回体积没有差异。这些结果表明，人类海马体在青春期期间正在进行强有力的成熟过程，尤其是男性。讨论了这些发现与髓鞘形成进展的可能相关性以及对精神疾病的影响。
To clarify the developmental brain changes during adolescence, brain morphology was compared between healthy younger adolescent and elder adolescent subjects using both voxel-based morphometry (VBM) and volumetric region-of-interest (ROI) analysis of magnetic resonance imaging (MRI). High-resolution three-dimensional MRI scans were acquired in 23 (10 males and 13 females) younger adolescent subjects (13-14 years) and 30 (15 males and 15 females) elder adolescent subjects (19-21 years). Whole-brain analysis by VBM revealed that the elder adolescent subjects had significantly more gray matter in the left medial temporal regions than the younger adolescent subjects and significantly less gray matter in the left medial frontal region (Brodmann area 6). In the volumetric analysis, significantly less cerebral gray matter volume and significantly greater cerebral white matter volume were found in elder adolescents compared with younger adolescents. The volume of the hippocampus was significantly larger in male elder adolescents than in male younger adolescents. The volume of the parahippocampal gyrus did not differ between younger and elder adolescent subjects. These results suggest a robust maturational process ongoing in the human hippocampus during adolescence, especially in males. The possible relevance of these findings to progress in myelination and implications in psychiatric disorders were discussed.