A brief overview of metal complexes as nuclear imaging agents.
A brief overview of metal complexes as nuclear imaging agents.
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作为核显像剂的金属配合物的简要概述。
DOI：
10.1039/c9dt03039e
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Zeglis,BrianM
中科院分区：
文献类型：
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作者：
MacPherson,DouglasS;Fung,Kimberly;Cook,BrendonE;Francesconi,LynnC;Zeglis,BrianM
金属放射性核素在核成像领域中的作用已经超过半个世纪。虽然近年来已经见证了放射性金属作为带有螯合剂的生物分子的标记物的使用的急剧增加，但仅基于放射性金属的配位化合物的成像剂长期以来也在该学科中发挥了关键作用。在这项工作中，我们试图提供一个简短的概述金属配合物为基础的放射性药物的正电子发射断层扫描（PET）和单光子发射计算机断层扫描（SPECT）。更具体地说，我们专注于成像剂，其中金属络合物本身，而不是悬垂的生物分子或靶向部分是负责示踪剂的体内行为。这个化合物家族包含基于不同核素阵列的金属络合物以及已用于多种病理成像的探针，包括感染，炎症，癌症和心脏病。事实上，过渡金属络合物的两个定义特征模块性和氧化还原化学都被创造性地利用在显像剂的开发中。根据我们的受众，特别关注结构和机制，尽管临床数据也得到了解决。最终，我们希望这篇综述不仅能让读者了解过去30年来在这一领域所做的一些开创性工作，还能激发人们对基于小金属络合物的放射性药物的新兴趣。
Metallic radionuclides have been instrumental in the field of nuclear imaging for over half a century. While recent years have played witness to a dramatic rise in the use of radiometals as labels for chelator-bearing biomolecules, imaging agents based solely on coordination compounds of radiometals have long played a critical role in the discipline as well. In this work, we seek to provide a brief overview of metal complex-based radiopharmaceuticals for positron emission tomography (PET) and single photon emission computed tomography (SPECT). More specifically, we have focused on imaging agents in which the metal complex itself rather than a pendant biomolecule or targeting moiety is responsible for the in vivo behavior of the tracer. This family of compounds contains metal complexes based on an array of different nuclides as well as probes that have been used for the imaging of a variety of pathologies, including infection, inflammation, cancer, and heart disease. Indeed, two of the defining traits of transition metal complexes—modularity and redox chemistry—have both been creatively leveraged in the development of imaging agents. In light of our audience, particular attention is paid to structure and mechanism, though clinical data is addressed as well. Ultimately, it is our hope that this review will not only educate readers about some of the seminal work performed in this space over the last 30 years but also spur renewed interest in the creation of radiopharmaceuticals based on small metal complexes.