Serum levels of 25-hydroxyvitamin D, oral health and chronic obstructive pulmonary disease
Serum levels of 25-hydroxyvitamin D, oral health and chronic obstructive pulmonary disease
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25-羟基维生素 D 的血清水平、口腔健康和慢性阻塞性肺疾病。
DOI：
10.1111/j.1600-051x.2012.01852.x
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发表时间：
2012-04-01
影响因子：
6.7
通讯作者：
Wang, Zuomin
中科院分区：
文献类型：
--
作者：
Zhou, Xuan;Han, Jing;Wang, Zuomin
目的：探讨血清25羟基维生素D[25(OH)D]水平与牙周健康及慢性阻塞性肺疾病(COPD)的关系。材料和方法：对193例COPD患者和181例对照进行病例对照研究。检查牙周状况和肺功能，测定血清25(OH)D水平。结果：慢性阻塞性肺疾病组血清25(OH)D平均浓度显著低于对照组(32.1nmol/L和35.8nmol/L；p=0.002)。非吸烟者血清25(OH)D浓度与肺功能呈正相关，有吸烟史者血清25(OH)D浓度与斑块指数(PLI)负相关。在调整了年龄、性别、体重指数、季节和吸烟状况后，牙周指数与血清25(OH)D浓度(所有组的剩余牙数；COPD组的探牙深度、临床附着水平、出血指数、PLI和牙槽骨丢失)显著相关。在调整牙周指数和其他变量后，较低的血清25(OH)D浓度与既往吸烟者患慢性阻塞性肺疾病的风险显著相关(奇数比4.11；95%可信区间1.47-11.5；p=0.007)。结论：较低的血清25(OH)D浓度与牙周健康不良和COPD风险增加显著相关。
Aim: To evaluate the associations of serum 25-Hydroxyvitamin D [ 25(OH) D] levels with periodontal health and chronic obstructive pulmonary disease (COPD). Material and Methods: We conducted a case-control study of 193 COPD patients and 181 controls. Their periodontal status and lung function were examined, and serum 25(OH) D levels were measured. Results: Mean serum 25(OH) D concentrations were significantly lower in the COPD group than in the controls (32.1 versus 35.8 nmol/ l; p = 0.002). Serum 25(OH) D concentrations were positively correlated with lung function among non-smokers and negatively correlated with plaque index (PLI) among former smokers. After adjustment for age, gender, body mass index, season and smoking status, periodontal indexes were significantly associated with serum 25(OH) D concentrations (number of remaining teeth among all groups; probing depth, clinical attachment level, bleeding index, PLI and alveolar bone loss among COPD group). Lower serum 25(OH) D concentrations were significantly associated with an increased risk of COPD among former smokers (Odd ratio 4.11; 95% confidence interval 1.47-11.5; p = 0.007) after adjustment for periodontal indexes and other variables. Conclusions: Lower serum 25(OH) D concentrations were significantly associated with poor periodontal health and an increased risk of COPD.