CORONAVIRUS INFECTION INDUCES H-2-ANTIGEN EXPRESSION ON OLIGODENDROCYTES AND ASTROCYTES
CORONAVIRUS INFECTION INDUCES H-2-ANTIGEN EXPRESSION ON OLIGODENDROCYTES AND ASTROCYTES
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DOI：
10.1126/science.3010460
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发表时间：
1986-05-23
期刊：
影响因子：
56.9
通讯作者：
SILBERBERG, DH
中科院分区：
文献类型：
--
作者：
SUZUMURA, A;LAVI, E;SILBERBERG, DH
小鼠肝炎病毒A59株感染中枢神经系统，可诱导小鼠少突胶质细胞和星形胶质细胞上的I类主要组织相容性复合体抗原，这些细胞在其表面通常不表达这些抗原。这种诱导通过受感染的神经胶质细胞精心设计的可溶性因子发生，潜在地允许免疫细胞与神经胶质细胞相互作用，并可能在病毒诱导的、免疫介导的中枢神经系统脱髓鞘的发病机制中发挥关键作用。
Infection of the central nervous system by mouse hepatitis virus strain A59, a murine neurotropic coronavirus, induces class I major histocompatibility complex antigens on mouse oligodendrocytes and astrocytes, cells that do not normally express these antigens on their surfaces. This induction, which occurs through soluble factors elaborated by infected glial cells, potentially allows immunocytes to interact with the glial cells and may play a critical role in the pathogenesis of virus-induced, immune-mediated demyelination in the central nervous system.