Early life exposures and the risk of adult glioma.
Early life exposures and the risk of adult glioma.
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早期生命暴露和成人神经胶质瘤的风险。
DOI：
10.1007/s10654-013-9811-1
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发表时间：
2013
影响因子：
13.6
通讯作者：
Egan,KathleenM
中科院分区：
文献类型：
--
作者：
Anic,GabriellaM;Madden,MelissaH;Sincich,Kelly;Thompson,ReidC;Nabors,LBurton;Olson,JeffreyJ;LaRocca,RenatoV;Browning,JamesE;Pan,Edward;Egan,KathleenM
在生命早期暴露于常见感染可能会刺激免疫发育并降低患癌症的风险。出生顺序和家庭规模是暴露于儿童感染的时间的代理，几项研究显示，与较高的出生顺序（以及假定的感染年龄较低）相关的胶质瘤风险降低。本研究的目的是检查出生顺序，家庭规模和其他早期生活暴露是否与成人胶质瘤的风险相关，使用的数据收集在一个大型的基于临床的美国病例对照研究，包括889例胶质瘤病例和903个社区对照。一个结构化的访谈管理问卷被用来收集有关家庭结构，儿童暴露和其他潜在的风险因素的信息。Logistic回归用于计算早期生活因素与胶质瘤风险之间关联的比值比（OR）和相应的95%置信区间（CI）。与没有兄弟姐妹的人相比，有任何兄弟姐妹的人患神经胶质瘤的风险显著降低（OR = 0.64; 95% CI 0.44-0.93;p= 0.020）。与第一次发病相比，有年长兄弟姐妹的个体的风险显著降低（OR = 0.75; 95% CI 0.61-0.91;p= 0.004）。出生体重、婴儿期母乳喂养、出生季节与胶质瘤风险无关。目前的研究结果进一步支持了越来越多的证据，即早期暴露于儿童感染可降低儿童和成人胶质瘤发病的风险。
Exposure to common infections in early life may stimulate immune development and reduce the risk for developing cancer. Birth order and family size are proxies for the timing of exposure to childhood infections with several studies showing a reduced risk of glioma associated with a higher order of birth (and presumed younger age at infection). The aim of this study was to examine whether birth order, family size, and other early life exposures are associated with the risk of glioma in adults using data collected in a large clinic-based US case-control study including 889 glioma cases and 903 community controls. A structured interviewer-administered questionnaire was used to collect information on family structure, childhood exposures and other potential risk factors. Logistic regression was used to calculate odds ratios (OR) and corresponding 95 % confidence intervals (CI) for the association between early life factors and glioma risk. Persons having any siblings were at significantly lower risk for glioma when compared to those reporting no siblings (OR = 0.64; 95 % CI 0.44–0.93;p= 0.020). Compared to first-borns, individuals with older siblings had a significantly lower risk (OR = 0.75; 95 % CI 0.61–0.91;p= 0.004). Birth weight, having been breast fed in infancy, and season of birth were not associated with glioma risk. The current findings lend further support to a growing body of evidence that early exposure to childhood infections reduces the risk of glioma onset in children and adults.