Alterations of the Erythrocyte Membrane during Sepsis.
Alterations of the Erythrocyte Membrane during Sepsis.
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DOI：
10.1155/2012/702956
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发表时间：
2012
影响因子：
1.7
通讯作者：
Piagnerelli M
中科院分区：
文献类型：
--
作者：
Serroukh Y;Djebara S;Lelubre C;Zouaoui Boudjeltia K;Biston P;Piagnerelli M
红细胞长期以来被认为是“死亡”细胞，其唯一功能是运输氧气。然而，红细胞（rbc）调节微循环的能力现在被认为是一个重要的附加功能。这种能力是由流变过程中的一个关键因素调节的：红细胞膜。该膜是一个复杂的单元，在细胞外和细胞内室之间有多种相互作用：一方面是血流、内皮和其他血细胞，另一方面是胞浆内室，可能快速适应红细胞代谢。在本文中，我们回顾了在危重病人中观察到的红细胞膜的改变以及这些改变对危重病人微循环异常的影响。了解脓毒症中红细胞流变学改变的机制及其对血流和氧运输的影响可能有助于降低严重脓毒症的发病率和死亡率。
Erythrocytes have been long considered as “dead” cells with transport of oxygen (O2) as their only function. However, the ability of red blood cells (RBCs) to modulate the microcirculation is now recognized as an important additional function. This capacity is regulated by a key element in the rheologic process: the RBC membrane. This membrane is a complex unit with multiple interactions between the extracellular and intracellular compartments: blood stream, endothelium, and other blood cells on the one hand, and the intracytoplasmic compartment with possible rapid adaptation of erythrocyte metabolism on the other. In this paper, we review the alterations in the erythrocyte membrane observed in critically ill patients and the influence of these alterations on the microcirculatory abnormalities observed in such patients. An understanding of the mechanisms of RBC rheologic alterations in sepsis and their effects on blood flow and on oxygen transport may be important to help reduce morbidity and mortality from severe sepsis.