Differences in fetal fractional limb volume changes in normal and gestational diabetic pregnancies: an exploratory observational study
Differences in fetal fractional limb volume changes in normal and gestational diabetic pregnancies: an exploratory observational study
复制标题
DOI：
10.1111/1471-0528.16265
复制
发表时间：
2020-05-03
影响因子：
5.8
通讯作者：
Tanaka, M.
中科院分区：
文献类型：
--
作者：
Akiba, Y.;Ikenoue, S.;Tanaka, M.
目的胎儿肢体分数体积是一种定量评价胎儿软组织发育的有效指标。本研究的目的是探讨与正常糖耐量（NGT）胎儿相比，母亲妊娠期糖尿病（GDM）胎儿的手臂体积分数（AVol）和大腿体积分数（THR）的增长。本研究假设妊娠晚期GDM组胎儿肢体分数体积大于NGT组。设计探索性观察研究。地点琦玉市立医院。样本共165例方法在妊娠20 ~ 37周对125例NGT和40例GDM单胎日本孕妇的AVol和Tvol进行评估，作为圆柱形肢体体积，基于50%胎儿肱骨或股骨骨干长度的。根据日本妇产科学会的标准诊断为GDM。比较NGT和GDM妇女在每个胎龄阶段（从孕20至37周间隔2周）的主要结局指标AVol和TdR。孕32周前各组AVol差异无统计学意义。妊娠32周后GDM组AVol显著大于NGT组（P < 0.05）。结论检测胎儿AVol的变化可以更好地了解GDM胎儿体比例改变的起源。妊娠32周后，GDM胎儿的AVol显著大于NGT胎儿，而TcR则无显著性差异。
Objective Fetal fractional limb volume has been proposed as a useful measure for quantifying fetal soft tissue development. The aim of this study was to investigate the growth of fractional arm volume (AVol) and fractional thigh volume (TVol) of fetuses with maternal gestational diabetes (GDM) compared with those of fetuses with normal glucose tolerance (NGT). We hypothesised fetal fractional limb volume would be larger in the GDM group than in the NGT group in late gestation.Design Exploratory observational study.Setting Saitama Municipal Hospital.Sample A total of 165 (125 NGT and 40 GDM) singleton Japanese pregnant women.Methods AVol and TVol were assessed between 20 and 37 weeks' gestation as cylindrical limb volumes based on 50% of the fetal humeral or femoral diaphysis length. Women were diagnosed as GDM based on the criteria of the Japan Society of Obstetrics and Gynecology.Main outcome measures AVol and TVol were compared between women with NGT and those with GDM at each gestational age period (2-week intervals from 20 to 37 weeks' gestation).Results Overall, 287 ultrasound scans were performed (NGT group, 205 scans; GDM group, 82 scans). There was no significant difference of AVol between the groups before 32 weeks' gestation. AVol was significantly larger in the GDM group than in the NGT group after 32 weeks' gestation (P < 0.05). TVol was not statistically different between the groups across gestation.Conclusions Detection of variations in fetal AVol may provide greater insight into understanding the origins of altered fetal body proportion in GDM.Tweetable abstract AVol, but not TVol, is significantly larger in fetuses with GDM than in those with NGT after 32 weeks' gestation.