The gut microbiota induces Peyer’s-patch-dependent secretion of maternal IgA into milk
The gut microbiota induces Peyer’s-patch-dependent secretion of maternal IgA into milk
复制标题
肠道微生物群诱导派尔氏集结依赖性母体 IgA 分泌到乳汁中
DOI：
10.1016/j.celrep.2021.109655
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发表时间：
2021
期刊：
影响因子：
8.8
通讯作者：
etc
中科院分区：
文献类型：
--
作者：
Usami Katsuki;Niimi Kanae;Matsuo Ayumi;Suyama Yoshihisa;Sakai Yoshifumi;Sato Shintaro;Fujihashi Kohtaro;Kiyono Hiroshi;Uchino Saeka;Furukawa Mutsumi;Islam Jahidul;etc
通过乳汁转移母体抗体的进化策略深刻地影响了所有新生儿的生存、终身健康和福祉，包括对人类母乳喂养成功和婴儿发育的显著影响。虽然人们越来越多地认识到，器官间的连接影响母乳的质量，可能会个性化它为她的后代，这些过程的基础是不完全解决。在这里，我们定义了一个必不可少的作用，派尔集合淋巴结（PP）的浆细胞分泌到牛奶中的母亲免疫球蛋白A（伊加）的产生。我们的宏基因组分析表明，胃肠道（GI）中某些驻留微生物的存在，如Bacteroides acidifaciens和Prevotella buccalis，是必不可少的编程母体伊加合成之前，哺乳转移。我们的数据提供了重要的见解，了解母体胃肠道环境的微生物组，特别是通过PP，如何通过乳汁传递给下一代。
The evolutionary strategy of transferring maternal antibodies via milk profoundly impacts the survival, lifelong health, and wellbeing of all neonates, including a pronounced impact on human breastfeeding success and infant development. While there has been increased recognition that interorgan connectivity influences the quality of a mother's milk, potentially to personalize it for her offspring, the underlying bases for these processes are incompletely resolved. Here, we define an essential role of Peyer's patches (PPs) for the generation of plasma cells that secrete maternal immunoglobulin A (IgA) into milk. Our metagenomic analysis reveals that the presence of certain residential microorganisms in the gastrointestinal (GI) tract, such asBacteroides acidifaciensandPrevotella buccalis, is indispensable for the programming of maternal IgA synthesis prior to lactational transfer. Our data provide important insights into how the microbiome of the maternal GI environment, specifically through PPs, can be communicated to the next generation via milk.