Zhixue capsule caused seven cases of drug induced hepatitis.
Zhixue capsule caused seven cases of drug induced hepatitis.
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发表时间：
2010-05
影响因子：
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通讯作者：
Wei-ping Tai;H. Yue;H. Zhai
中科院分区：
文献类型：
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作者：
Wei-ping Tai;H. Yue;H. Zhai
目的报道我科最近7例药物性肝炎。方法2008年10月至2008年12月，我科收治7例因服用止血胶囊引起药物性肝炎的患者。止血胶囊由白藓皮和苦参组成。有4名女性和3名男性患者。患者年龄在31至52岁之间。其中肝细胞损伤型6例，混合型1例。止血胶囊给药时间为6 ~ 18天。患者入组我科时，均接受黄疸和保肝治疗。结果患者出院时症状明显改善，肝功能恢复正常。1例混合型患者住院63天，给予糖皮质激素治疗，以帮助其恢复。结论止血胶囊可诱发多种类型的急性肝炎，但以肝细胞损伤型为主。所有类型的患者经适当治疗均可恢复。合并型可能需要糖皮质激素的管理，以帮助恢复。
BACKGROUND/AIMS To report the recently 7 cases of drug induced hepatitis patients in our department. METHODOLOGY From October 2008 to December 2008, 7 patients were enrolled in our department for drug induced hepatitis caused by Zhixue capsules administration. The Zhixue capsule is composed of cortex dictam and radices sophorae flavescentis. There were 4 female and 3 male patients. The patients were of age 31 to 52 years old. Of those, 6 patients belonged to the hepatocellular injury type and one to the mixed type. The time period Zhixue capsule was administered was from 6 to 18 days. When the patients enrolled into our department, they were treated for jaundice and protective liver function. RESULTS When the patients were discharged the symptoms were all improved evidently and liver function became normal. One patient with mixed type was hospitalized for 63 days and he was treated with glucocorticoid to help his recovery. CONCLUSIONS Zhixue capsule could induce acute hepatitis of various types, but mainly hepatocellular injury type. The patients of all types could be recovered with proper treatment. The combined type may need glucocorticoid administration to help recovery.