Transcranial magnetic stimulation reveals two cortical pathways for visual body processing
Transcranial magnetic stimulation reveals two cortical pathways for visual body processing
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DOI：
10.1523/jneurosci.0789-07.2007
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发表时间：
2007-07-25
影响因子：
5.3
通讯作者：
Aglioti, Salvatore M.
中科院分区：
文献类型：
--
作者：
Urgesi, Cosimo;Calvo-Merino, Beatriz;Aglioti, Salvatore M.
对于倒置演示来说，对人体的视觉识别比直立演示更困难。这种身体倒置效应意味着身体感知依赖于结构而不是局部加工。尽管神经成像研究表明，人体的视觉处理涉及一个巨大的额颞顶网络，但关于身体结构处理的神经基础的信息很少。在这里，我们使用重复的经颅磁刺激(RTMS)来研究运动前区、视觉区和顶区在人体结构处理中的因果作用。18名受试者以直立或倒立的静态体态完成了延迟的样本匹配任务。在样本刺激开始150ms后，对左侧腹侧运动前皮质(VPMc)、右侧纹状体外体区(EBA)和右侧顶上叶(SPL)进行事件相关双脉冲rTMS检查，并以右侧初级视觉皮质(V1)为对照。对vPMc的干扰刺激显著降低了对直立身体的匹配判断的准确性。相比之下，EBA rTMS显著降低了倒立身体的准确性，但对直立身体没有影响。此外，干扰刺激EBA和V1后，可观察到显著的身体翻转效应，而对vPMc和SPL则无明显影响。这些结果证明了额顶镜像网络对身体结构加工的积极贡献，并暗示了视觉知觉的一个新的、具体化的方面。相比之下，身体的局部加工，可能基于身体个别部位的形式，而不是整个身体单位，似乎依赖于EBA。因此，我们提出了人体视觉处理的两种不同的大脑皮层路径。
Visual recognition of human bodies is more difficult for upside down than upright presentations. This body inversion effect implies that body perception relies on configural rather than local processing. Although neuroimaging studies indicate that the visual processing of human bodies engages a large fronto-temporo-parietal network, information about the neural underpinnings of configural body processing is meager. Here, we used repetitive transcranial magnetic stimulation (rTMS) to study the causal role of premotor, visual, and parietal areas in configural processing of human bodies. Eighteen participants performed a delayed matching-to-sample task with upright or inverted static body postures. Event-related, dual-pulse rTMS was applied 150 ms after the sample stimulus onset, over left ventral premotor cortex (vPMc), right extrastriate body area (EBA), and right superior parietal lobe (SPL) and, as a control site, over the right primary visual cortex (V1). Interfering stimulation of vPMc significantly reduced accuracy of matching judgments for upright bodies. In contrast, EBA rTMS significantly reduced accuracy for inverted but not for upright bodies. Furthermore, a significant body inversion effect was observed after interfering stimulation of EBA and V1 but not of vPMc and SPL. These results demonstrate an active contribution of the fronto-parietal mirror network to configural processing of bodies and suggest a novel, embodied aspect of visual perception. In contrast, the local processing of the body, possibly based on the form of individual body parts instead of on the whole body unit, appears to depend on EBA. Therefore, we propose two distinct cortical routes for the visual processing of human bodies.