Right-Sided Human Prefrontal Brain Activation During Acquisition of Conditioned Fear
Right-Sided Human Prefrontal Brain Activation During Acquisition of Conditioned Fear
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DOI：
10.1037/1528-3542.2.3.233
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发表时间：
2002-09-01
期刊：
影响因子：
4.2
通讯作者：
Fredrikson, Mats
中科院分区：
文献类型：
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作者：
Fischer, Hakan;Andersson, Jesper L. R.;Fredrikson, Mats
这项(H2O)-O-15正电子发射断层扫描(PET)研究报告了人类恐惧条件反射过程中相对局部脑血流量(RCBF)的变化。在PET扫描仪中，受试者观看电视屏幕，屏幕上单独显示视觉白噪音或蛇的录像带，然后是电击，然后是白噪音和蛇的最终演示。自主神经系统的反应证实了恐惧条件反射只对蛇起作用。为了揭示在获取过程中的神经激活，同时等同于感觉刺激，在蛇的扫描中，只有电击和白噪音，与只有电击和蛇的白噪音进行了对比。在获得过程中，右侧额叶内侧回的rCBF增加，支持前额叶皮质在恐惧条件反射中对未掩饰的进化恐惧相关刺激的作用。
This (H2O)-O-15 positron emission tomography (PET) study reports on relative regional cerebral blood flow (rCBF) alterations during fear conditioning in humans. In the PET scanner, subjects viewed a TV screen with either visual white noise or snake videotapes displayed alone, then with electric shocks, followed by final presentations of white noise and snakes. Autonomic nervous system responses confirmed fear conditioning only to snakes. To reveal neural activation during acquisition, while equating sensory stimulation, scans during snakes with shocks and white noise alone were contrasted against white noise with shocks and snakes alone. During acquisition, rCBF increased in the right medial frontal gyrus, supporting a role for the prefrontal cortex in fear conditioning to unmasked evolutionary fear-relevant stimuli.