Previous Infection Positively Correlates to the Tumor Incidence Rate of Patients with Cancer
Previous Infection Positively Correlates to the Tumor Incidence Rate of Patients with Cancer
复制标题
DOI：
10.1158/2326-6066.cir-19-0510
复制
发表时间：
2020-05-01
影响因子：
10.1
通讯作者：
Matsuno, Shigeo
中科院分区：
文献类型：
--
作者：
Inaida, Shinako;Matsuno, Shigeo
我们对30岁以上人群进行了一项为期7年的病例对照研究，了解流感、胃肠炎、肝炎和肺炎感染的流行情况，以间接检验这些感染是否与恶性癌症的形成相关。数据提取自日本社会健康保险系统的大型医疗索赔数据库；病例组包括 2,354 名在本研究第 7 年首次诊断出癌症的人，对照组包括 48,395 名在第 7 年未诊断出癌症的人。在整个研究期间，流感、胃肠炎、肝炎和肺炎感染的年患病率有所增加。癌症检测前 1 年病例的年龄调整 OR 和 95% 置信区间 (CI) 显着较高 - 流感 1.29 (95% CI, 1.14-1.46)、胃肠炎 1.60 (95% CI, 1.41-1.82)、肝炎 3.38 (95% CI, 2.12-5.37)、肺炎 2.36 (95% CI) CI，1.79-3.13），这四种疾病中的任何一种为 1.55（95% CI，1.40-1.70）。在流感感染中，仅在癌症诊断前的第 2 年和第 6 年才发现显着的 OR。对于每个癌症部位，在癌症诊断之前观察到感染率有所增加。在这里，我们发现癌前阶段感染的增加可能是肿瘤诱导的免疫抑制的替代品，与最终的癌症发展相关。
We conducted a 7-year case-control study of people >= 30 years of age on the prevalence of influenza, gastroenteritis, hepatitis, and pneumonia infections to indirectly examine whether these infections correlated to malignant cancer formation. Data were extracted from a large medical claims database of a Japanese social health insurance system; the case group included 2,354 people with their first cancer diagnosis in the 7th year of this study, and the control group included 48,395 people with no cancer diagnosis by the 7th year. The yearly prevalence rates of influenza, gastroenteritis, hepatitis, and pneumonia infections increased throughout the study period. Age-adjusted ORs and 95% confidence intervals (CI) in cases 1 year before cancer detection were significantly higher-for influenza 1.29 (95% CI, 1.14-1.46), for gastroenteritis 1.60 (95% CI, 1.41-1.82), for hepatitis 3.38 (95% CI, 2.12-5.37), for pneumonia 2.36 (95% CI, 1.79-3.13), and for any of these four diseases 1.55 (95% CI, 1.40-1.70). In influenza infections, significant ORs were found only in the 2nd and 6th years before cancer diagnosis. For each cancer site, an increased rate of infection prior to cancer diagnosis was observed. Here, we showed that increased infections during the precancerous stage, a possible surrogate for tumor-induced immune suppression, correlated to eventual cancer development.