Endometrial NK cells are special immature cells that await pregnancy
Endometrial NK cells are special immature cells that await pregnancy
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DOI：
10.4049/jimmunol.181.3.1869
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发表时间：
2008-08-01
影响因子：
4.4
通讯作者：
Mandelboim, Ofer
中科院分区：
文献类型：
--
作者：
Manaster, Irit;Mizrahi, Saar;Mandelboim, Ofer
怀孕前，NK细胞在人子宫内膜中繁殖。与怀孕期间填充蜕膜的NK细胞不同，怀孕前存在于人子宫内膜中的NK细胞尚未完全表征。在这项研究中，我们提供了子宫内膜NK细胞（eNK）的起源，表型和功能的详细分析。我们发现eNK细胞具有独特的受体库。特别是，它们对NKp30和趋化因子受体的表达是阴性的，这将它们与迄今为止描述的任何其他NK亚群区分开来。我们进一步表明，在IL-15刺激前，eNK细胞缺乏nk特异性功能表型和活性，如细胞因子分泌和细胞毒性。在这种刺激下，子宫内膜NK细胞获得了与蜕膜NK细胞相似的表型和功能。因此，我们认为eNK细胞是一种失活细胞（在IL-15激活之前，与已知的NK活性相关），存在于受孕前的子宫内膜中，等待怀孕。
NK cells populate the human endometrium before pregnancy. Unlike decidual NK cells that populate the decidua during pregnancy, the NK cells present in the human endometrium, before pregnancy, have not been fully characterized. In this study, we provide a detailed analysis of the origin, phenotype, and function of endometrial NK cells (eNK). We show that eNK cells have a unique receptor repertoire. In particular, they are negative for NKp30 and chemokine receptor expression, which distinguishes them from any other NK subset described so far. We further show that eNK cells lack NK-specific functional phenotype and activity such as cytokine secretion and cytotoxicity, before IL-15 stimulation. Following such stimulation, endometrial NK cells acquire phenotype and function that are similar to those of decidual NK cells. We therefore suggest that eNK cells are inactive cells (before IL-15 activation and in relation to the known NK activity) that are present in the endometrium before conception, waiting for pregnancy.