Characteristics of hepatocellular carcinoma in cirrhotic and non-cirrhotic non-alcoholic fatty liver disease
Characteristics of hepatocellular carcinoma in cirrhotic and non-cirrhotic non-alcoholic fatty liver disease
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DOI：
10.3748/wjg.v21.i4.1189
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发表时间：
2015-01-28
影响因子：
4.3
通讯作者：
Angus, Peter W.
中科院分区：
文献类型：
--
作者：
Leung, Christopher;Yeoh, Sern Wei;Angus, Peter W.
目的：为了确定与非酒精性脂肪性肝病（NAFLD）相关的肝细胞癌（HCC）患者的特征和预后预测因素，我们回顾了2000年至2012年期间所有与NAFLD相关的HCC患者的记录。收集的数据包括人口统计学;组织学;肝硬化的存在或不存在，HCC的大小和数量，甲胎蛋白，体重指数（BMI），以及糖尿病，高血压或血脂异常的存在。平均年龄为64岁，87%为男性。15%（8/54）的患者未出现腹泻。11%、24%和50%的人的BMI分别为< 25 kg/m2、25-29 kg/m2和>= 30 kg/m2。59%患有糖尿病，44%患有高血压，26%患有高脂血症。34%的患者
AIM: To determine characteristics and prognostic predictors of patients with hepatocellular carcinoma (HCC) in association with non-alcoholic fatty liver disease (NAFLD).METHODS: We reviewed the records of all patients with NAFLD associated HCC between 2000 and 2012. Data collected included demographics; histology; presence or absence of cirrhosis, size and number of HCC, alpha-fetoprotein, body mass index (BMI), and the presence of diabetes, hypertension, or dyslipidaemia.RESULTS: Fifty-four patients with NAFLD associated HCC were identified. Mean age was 64 years with 87% male. Fifteen percent (8/54) were not cirrhotic. 11%, 24% and 50% had a BMI of < 25 kg/m2, 25-29 kg/m(2) and >= 30 kg/m(2) respectively. Fifty-nine percent were diabetic, 44% hypertensive and 26% hyperlipidaemic. Thirty-four percent of the patients had