Impact of Repetitive Transcranial Magnetic Stimulation to the Cerebellum on Performance of a Ballistic Targeting Movement
Impact of Repetitive Transcranial Magnetic Stimulation to the Cerebellum on Performance of a Ballistic Targeting Movement
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DOI：
10.1007/s12311-022-01438-9
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发表时间：
2022-07-04
期刊：
影响因子：
3.5
通讯作者：
Saitoh, Youichi
中科院分区：
文献类型：
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作者：
Matsugi, Akiyoshi;Nishishita, Satoru;Saitoh, Youichi
本研究旨在探讨重复性经颅磁刺激（rTMS）对一系列重复性弹道瞄准任务中小脑运动性能变化的影响。22名健康的年轻人参加了本研究，其中主动rTMS组n = 12，假性rTMS组n = 10。参与者坐在显示器前的椅子上，将右前臂固定在操纵杆上。他们用手腕的弯曲/伸展来操纵手柄来移动显示器上的杆。在哔的一声响起后，参与者立即将棒子尽可能快地移动到目标线上。在弹道瞄准任务的前10次重复后，对右小脑施加主动或假rTMS （1hz， 900脉冲）。随后，进行了五组，每组100次重复。假性rTMS组的参与者在重复后的反应时间、运动时间、最大运动速度和瞄准误差都有所改善。然而，主动rtms组的改善受到抑制。在重复的弹道瞄准任务中，低频小脑rTMS可能会破坏运动学习。这支持了小脑在弹道瞄准运动中参与运动学习和运动错误纠正的假设。
This study aimed to investigate the effects of repetitive transcranial magnetic stimulation (rTMS) of the cerebellum on changes in motor performance during a series of repetitive ballistic-targeting tasks. Twenty-two healthy young adults (n = 12 in the active-rTMS group and n = 10 in the sham rTMS group) participated in this study. The participants sat on a chair in front of a monitor and fixed their right forearms to a manipulandum. They manipulated the handle with the flexion/extension of the wrist to move the bar on the monitor. Immediately after a beep sound was played, the participant moved the bar as quickly as possible to the target line. After the first 10 repetitions of the ballistic-targeting task, active or sham rTMS (1 Hz, 900 pulses) was applied to the right cerebellum. Subsequently, five sets of 100 repetitions of this task were conducted. Participants in the sham rTMS group showed improved reaction time, movement time, maximum velocity of movement, and targeting error after repetition. However, improvements were inhibited in the active-rTMS group. Low-frequency cerebellar rTMS may disrupt motor learning during repetitive ballistic-targeting tasks. This supports the hypothesis that the cerebellum contributes to motor learning and motor-error correction in ballistic-targeting movements.