Dynamic Resting-State Functional Connectivity in Major Depression
Dynamic Resting-State Functional Connectivity in Major Depression
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DOI：
10.1038/npp.2015.352
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发表时间：
2016-06-01
影响因子：
7.6
通讯作者：
Pizzagalli, Diego A.
中科院分区：
文献类型：
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作者：
Kaiser, Roselinde H.;Whitfield-Gabrieli, Susan;Pizzagalli, Diego A.
重度抑郁障碍(MDD)的特点是静息状态功能连接异常(RSFC)，特别是在默认网络的内侧前额叶皮质(MPFC)区域。然而，之前对MDD的研究并没有研究随着网络的形成、相互作用和随着时间的推移而解散时功能连接的动态变化。我们比较了100名患有MDD的未服药个体和109名对照受试者在静息状态功能磁共振成像扫描期间对MPFC种子区的动态RSFC(在一系列滑动窗口上作为SD操作)的研究。在患有MDD的参与者中，我们还调查了症状严重程度与RSFC的关系。二次分析探讨了动态RSFC与反思冥想之间的关系。结果显示，MDD患者的特征是MPFC和默认网络内的海马旁回区域之间的动态(变量较少)RSFC降低，这种模式与这些区域之间跨越滑动窗口的持续正连接有关。相反，MDD组MPFC和岛叶区域之间的动态RSFC增加(变异性更大)，抑郁程度越高与MPFC和背外侧前额叶皮质之间的动态RSFC增加有关。这些高度可变的RSFC模式与滑动窗口活动中强烈的正相关和负相关的频率更高相关。二次分析表明，MPFC和ILAB之间动态RSFC的增加与较高的近期反省水平有关。这些发现提供了初步证据，表明抑郁症和抑郁症中的反思性思维与参与调节注意力和自我参照思维的大脑系统之间波动通信的异常模式有关。
Major depressive disorder (MDD) is characterized by abnormal resting-state functional connectivity (RSFC), especially in medial prefrontal cortical (MPFC) regions of the default network. However, prior research in MDD has not examined dynamic changes in functional connectivity as networks form, interact, and dissolve over time. We compared unmedicated individuals with MDD (n=100) to control participants (n = 109) on dynamic RSFC (operationalized as SD in RSFC over a series of sliding windows) of an MPFC seed region during a resting-state functional magnetic resonance imaging scan. Among participants with MDD, we also investigated the relationship between symptom severity and RSFC. Secondary analyses probed the association between dynamic RSFC and rumination. Results showed that individuals with MDD were characterized by decreased dynamic (less variable) RSFC between MPFC and regions of parahippocampal gyms within the default network, a pattern related to sustained positive connectivity between these regions across sliding windows. In contrast, the MDD group exhibited increased dynamic (more variable) RSFC between MPFC and regions of insula, and higher severity of depression was related to increased dynamic RSFC between MPFC and dorsolateral prefrontal cortex. These patterns of highly variable RSFC were related to greater frequency of strong positive and negative correlations in activity across sliding windows. Secondary analyses indicated that increased dynamic RSFC between MPFC and insula was related to higher levels of recent rumination. These findings provide initial evidence that depression, and ruminative thinking in depression, are related to abnormal patterns of fluctuating communication among brain systems involved in regulating attention and self-referential thinking.