Blue-Light Photocleavable Protecting Groups Based on Benzothiadiazole Scaffolds
Blue-Light Photocleavable Protecting Groups Based on Benzothiadiazole Scaffolds
复制标题
基于苯并噻二唑支架的蓝光光裂解保护基
DOI：
10.1021/acs.orglett.9b04268
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发表时间：
2019
期刊：
影响因子：
5.2
通讯作者：
VanVeller, Brett
中科院分区：
文献类型：
--
作者：
Norris, Sean;Warner, Caroline C.;Thooft, Andrea M.;Demirci, Selin K.;Lampkin, Bryan J.;Miner, Kyle;Ellern, Arkady;VanVeller, Brett
一个意想不到的亲核芳族取代导致一种新的苯并噻二唑支架，其具有与苄基型光可裂解保护基团相关的官能团模式。这种新分子在蓝光下显示出高效的离去基团的光化学释放。邻位和间位取代衍生物的性能通过结构操作和计算度量来提高性能。
An unexpected nucleophilic aromatic substitution lead to a novel benzothiadiazole scaffold that bore the functional group pattern associated with benzyl-type photocleavable protecting groups. The new molecules display efficient photochemical release of leaving groups with blue light. The performance of both ortho- and meta-substituted derivatives was probed through both structural manipulation and computational metrics to improve performance.