Molecular mechanisms and clinical applications of ginseng root for cardiovascular disease.
Molecular mechanisms and clinical applications of ginseng root for cardiovascular disease.
复制标题
DOI：
--
复制
发表时间：
2004-08
期刊：
影响因子：
--
通讯作者：
Wei Zhou;H. Chai;P. Lin;A. Lumsden;Q. Yao;Changyi J. Chen
中科院分区：
文献类型：
--
作者：
Wei Zhou;H. Chai;P. Lin;A. Lumsden;Q. Yao;Changyi J. Chen
人参根因其所谓的滋补作用和可能的治疗和恢复特性而广泛用于传统中医。有越来越多的证据在文献中的潜在作用，人参在治疗心血管疾病。我们在此研究了人参的使用历史，并回顾了目前关于人参对心血管系统的无数药理作用的文献。从已发表的涉及细胞培养和动物模型的研究中，人参被证明通过多种机制对心血管系统具有潜在的益处，包括抗氧化剂，改变血管功能，减少血小板粘附，影响离子通道，改变自主神经递质释放，改善脂质分布，并参与葡萄糖代谢和血糖控制。此外，对人参对心血管疾病的影响，特别是在控制高血压和改善心血管功能方面的相关临床试验进行了总结。最后，讨论了文献中的争议以及人参与其他药物之间可能的不良相互作用。这篇综述强调了人参对心血管疾病的潜在益处，突出了我们目前研究的差距，并强调了进行更严格的系统研究的必要性。
Ginseng root is used extensively in traditional Chinese medicine for its alleged tonic effect and possible curative and restorative properties. There are increasing evidences in the literature on the potential role of ginseng in treating cardiovascular diseases. We herein examine the history of ginseng usage and review the current literature on a myriad pharmacological function of ginseng on the cardiovascular system. From the published studies involving cell cultures and animal models, ginseng is shown to have potential benefits on the cardiovascular system through diverse mechanisms, including antioxidant, modifying vasomotor function, reducing platelet adhesion, influencing ion channels, altering autonomic neurotransmitters release, improving lipid profiles, and involving in glucose metabolism and glycemic control. In addition, the relevant clinical trials regarding the effects of ginseng on the cardiovascular disease are summarized, particularly in managing hypertension and improving cardiovascular function. Finally, the controversies in the literature and the possible adverse interactions between ginseng and other drugs are discussed. This review underscores the potential benefit effects of ginseng on cardiovascular diseases, highlights the gaps in our current research, and emphasizes the necessity for more rigorous systemic investigation.