Effect of inhibition of angiotensin converting enzyme and/or neutral endopeptidase on vascular and neural complications in high fat fed/low dose streptozotocin-diabetic rats.
Effect of inhibition of angiotensin converting enzyme and/or neutral endopeptidase on vascular and neural complications in high fat fed/low dose streptozotocin-diabetic rats.
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抑制血管紧张素转化酶和/或中性内肽酶对高脂肪喂养/低剂量/低剂量链霉菌蛋白糖尿病糖尿病大鼠血管和神经并发症的影响。
DOI：
10.1016/j.ejphar.2011.12.003
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发表时间：
2012-02-29
影响因子：
5
通讯作者：
Yorek, Mark A.
中科院分区：
文献类型：
--
作者：
Davidson, Eric P.;Coppey, Lawrence J.;Holmes, Amey;Yorek, Mark A.
关键词：
Treating high fat fed/low dose streptozotocin-diabetic rats; model of type 2 diabetes, with ilepatril (vasopeptidase inhibitor, blocks neutral endopeptidase (NEP) and angiotensin converting enzyme (ACE)) improved vascular and neural function. Next, studies were performed to determine the individual effect of inhibition of NEP and ACE on diabetes-induced vascular and neural dysfunction. High fat fed rats (8 weeks) were treated with 30 mg/kg streptozotocin (i.p.) and after 4 additional weeks, were treated for 12 weeks with ilepatril, enalapril (ACE inhibitor) or candoxatril (NEP inhibitor) followed by analysis of vascular and neural function. Glucose clearance was impaired in diabetic rats and was not improved with treatment although treatment with ilepatril or candoxatril partially improved insulin stimulated glucose uptake by isolated soleus muscle. Diabetes caused slowing of motor and sensory nerve conduction, thermal hypoalgesia, reduction in intraepidermal nerve fiber (IENF) profiles and impairment in vascular relaxation to acetylcholine and calcitonin gene-related peptide (CGRP) in epineurial arterioles of the sciatic nerve. Inhibition of NEP improved nerve conduction velocity and inhibition of NEP or ACE improved thermal sensitivity and protected IENF density. Ilepatril and candoxatril treatment of diabetic rats was efficacious in improving vascular responsiveness to acetylcholine in epineurial arterioles; whereas all three treatments improved vascular response to CGRP. These studies suggest that inhibition of NEP and ACE activity is an effective approach for treatment of type 2 diabetes neural and vascular complications.
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影响因子：
7.7
作者：
Miyashita K;Itoh H;Tsujimoto H;Tamura N;Fukunaga Y;Sone M;Yamahara K;Taura D;Inuzuka M;Sonoyama T;Nakao K
通讯作者：
Nakao K
DOI：
10.3317/jraas.2003.037
发表时间：
2003-12-01
影响因子：
2.9
作者：
Ebihara, T;Di Marco, GS;Casarini, DE
通讯作者：
Casarini, DE
影响因子：
7.7
作者：
Davidson, Eric P.;Kleinschmidt, Travis L.;Yorek, Mark A.
通讯作者：
Yorek, Mark A.
影响因子：
5
作者：
Davidson, Eric P.;Coppey, Lawrence J.;Yorek, Mark A.
通讯作者：
Yorek, Mark A.
影响因子：
6.9
作者：
Oltman, Christine L.;Davidson, Eric P.;Yorek, Mark A.
通讯作者：
Yorek, Mark A.