Potential occupational risks for neurodegenerative diseases
Potential occupational risks for neurodegenerative diseases
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DOI：
10.1002/ajim.20178
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发表时间：
2005-07-01
影响因子：
3.5
通讯作者：
Dosemeci, M
中科院分区：
文献类型：
--
作者：
Park, RM;Schulte, PA;Dosemeci, M
背景职业与神经退行性疾病（NDD）之间的关联可以从死亡证明数据中看出。方法采用1992-1998年22个州的数据对1982 - 1991年研究中提出的假设进行检验。评估了特定职业和暴露于杀虫剂、溶剂、氧化应激源、磁场和焊接烟雾的情况。结果大约三分之一（26187）的职业假设与神经退行性相关，相同结果的死亡率比值比（MOR）有统计学显著升高。MORs最大的职业是(a)老年痴呆症（PSD）牙医、评分员/分拣员（非农业）和神职人员；(b)阿尔茨海默病（AD）——银行柜员、神职人员、飞机机械师和理发师；(c)帕金森病——生物科学家、神职人员、宗教工作者和高等教育教师；(d)运动神经元疾病（MND）——兽医、美发师、分级和分拣员（非农业）。教师对所有四种疾病的MORs都显著升高，理发师对四种疾病中的三种的MORs都显著升高。65岁以下的非园艺农民PD （MOR = 2.23, 95% CI = 1.47-3.26）、PSD （MOR = 2.22, 95% CI = 1.10-4.05）和AD （MOR = 1.76, 95% CI = 1.04-2.81）升高。60赫兹磁场对AD、65岁以下PD （MOR= 1.87, 95% CI=1.14-2.98）和MND （MOR=1.63, 95% CI=1.10-2.39）表现出显著的暴露反应。焊接导致65岁以下帕金森病死亡率升高（MOR = 1.77, 95% CI = 1.08-2.75）。结论：支持与各种职业、60hz磁场和焊接相关的假设过度神经退行性疾病。2005年Wiley-Liss出版。
Background Associations between occupations and neurodegenerative diseases (NDD) may be discernable in death certificate data.Methods Hypotheses generated from 1982 to 1991 study were tested in data from 22 states for the years 1992-1998. Specific occupations and exposures to pesticides, solvents, oxidative stressors, magnetic fields, and welding fumes were evaluated.Results About one third (26187) of the occupations hypothesized with neurodegenerative associations had statistically significant elevated mortality odds ratios (MOR)for the same outcome. Occupations with the largest MORs were (a) for presenile dementia (PSD)dentists, graders/sorters (non-agricultural), and clergy; (b) for Alzheimer's disease (AD)-bank tellers, clergy, aircraft mechanics, and hairdressers; (c) for Parkinson's disease (PD)-biological scientists, clergy, religious workers, and post-secondary teachers; and (d) for motor neuron disease (MND)-veterinarians, hairdressers, and graders and sorters (non-agricultural). Teachers had significantly, elevated MORs for all four diseases, and hairdressers for three of the four. Non -horticultural farmers below age 65 had elevated PD (MOR = 2.23, 95% CI = 1.47-3.26), PSD (MOR = 2.22, 95% CI = 1.10-4.05), and AD (MOR = 1.76, 95% CI = 1.04-2.81). Sixty hertz magnetic fields exhibited significant exposure-response for AD and, below age 65, for PD (MOR = 1.87, 95% CI=1.14-2.98) and MND (MOR=1.63, 95% CI=1.10-2.39). Welding had elevated PD mortality below age 65 (MOR = 1.77, 95% CI = 1.08-2.75).Conclusions Support was observed for hypothesized excess neurodegenerative disease associated with a variety, of occupations, 60 Hz magnetic fields and welding. Published 2005 Wiley-Liss, Inc.