Hemodynamic signals correlate tightly with synchronized gamma oscillations
Hemodynamic signals correlate tightly with synchronized gamma oscillations
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DOI：
10.1126/science.1110948
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发表时间：
2005-08-05
期刊：
影响因子：
56.9
通讯作者：
Galuske, RAW
中科院分区：
文献类型：
--
作者：
Niessing, J;Ebisch, B;Galuske, RAW
功能成像方法通过测量血液动力学信号来监测神经活动。这些与局部场电位（LFP）的关系比与动作电位的关系更密切。我们同时记录了猫视觉皮层的电和血流动力学反应。增加刺激强度增强尖峰活动，高频LFP振荡和血流动力学反应。随着恒定的刺激强度，血流动力学反应的波动，这些波动只是松散的动作电位频率，但密切相关的伽玛范围内的LFP振荡的功率。这些振荡随着突触事件的同步性而增加，这表明血流动力学反应和神经元同步性之间密切相关。
Functional imaging methods monitor neural activity by measuring hemodynamic signals. These are more closely related to local field potentials (LFPs) than to action potentials. We simultaneously recorded electrical and hemodynamic responses in the cat visual cortex. Increasing stimulus strength enhanced spiking activity, high-frequency LFP oscillations, and hemodynamic responses. With constant stimulus intensity, the hemodynamic response fluctuated; these fluctuations were only loosely related to action potential frequency but tightly correlated to the power of LFP oscillations in the gamma range. These oscillations increase with the synchrony of synaptic events, which suggests a close correlation between hemodynamic responses and neuronal synchronization.