Complement system proteins which interact with C3b or C4b A superfamily of structurally related proteins.
Complement system proteins which interact with C3b or C4b A superfamily of structurally related proteins.
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与 C3b 或 C4b 相互作用的补体系统蛋白 结构相关蛋白的超家族。
DOI：
10.1016/0167-5699(86)90110-6
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
B. Tack
中科院分区：
文献类型：
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作者：
K. Reid;D. Bentley;R. Campbell;L. P. Chung;Robert B Sim;T. Kristensen;B. Tack
最近的cDNA测序数据可以预测补体成分因子B和C2的整个氨基酸序列，补体控制蛋白因子H和C4b结合蛋白以及C3b/C4b受体cr1的部分序列。这些蛋白质都含有大约60个氨基酸的内部重复单元，每个重复单元具有高度保守残基的特征框架。因子B和C2的n端Ba和C2b部分均含有3个重复单元，c4b结合蛋白链和因子H链分别含有8个和20个重复单元，而CR1中的精确单位数量尚不清楚。这些结构上同源的补体蛋白也在功能上相关，因为它们在级联激活过程中都与C3b和C4b相互作用。重复单元也出现在功能无关的蛋白质亚组分clr、~ 2糖蛋白I、凝血因子XIII和白介素-2受体中。在这篇综述中，Ken Reid和他的同事提出，这可能是结构相关蛋白超家族的一个普遍特征。补体系统由至少20种血浆糖蛋白组成。这个数字包括7个控制蛋白，以及13个经典途径和替代途径的组成部分，这些途径是系统激活发生的良好表征途径1-3（图1）。补体系统的许多生物效应（可能涉及炎症反应的诱导、细菌和病毒的吞噬、杀伤和裂解）是由多种细胞受体介导的，如C3blC4b受体（CRI），它可以结合活化成分（主要是C3blC4b）或由控制蛋白如酶因子I及其辅助因子因子H (H)的作用在这些活化成分的有限蛋白水解中产生的片段。CRI和c4b结合蛋白（C4BP）。这三组与补体系统相关的蛋白质的一个特征，即组件、控制蛋白和受体，是在每组中存在两种或更多与C3b或C4b相互作用的蛋白质（图1）。Holers等人最近在《Immunology Today》上综述了控制蛋白C4BP和H、膜结合蛋白CRI、衰变加速因子（DAF）和糖蛋白45-70 （gp 45-70）的生物化学和遗传学，指出了这些蛋白之间的功能相似性。然而，从详细的结构研究中发现了一个有趣的特征，即除了显示功能同源性外，控制蛋白C4BP和H以及受体CRI显示出一种不同寻常的结构同源性，这种同源性与组分C2、因子B和子组分Clr以及至少三个组分共享
Recent cDNA sequencing data has allowed the prediction of the entire amino acid sequences of complement components factor B and C2, the complement control proteins factor H and C4b-binding protein and a partial sequence for the C3b/C4b receptor CR 1. These proteins all contain internal repeating units of approximately 60 amino acids, each repeating unit having a characteristic framework of highly conserved residues. The N-terminal Ba and C2b portions of factor B and C2 both contain 3 repeating units and the chains of C4b-binding protein and factor H contain 8 and 20 repeating units, respectively, while the precise number of units in CR1 is not known yet. These structurally homologous complement proteins are also functionally related as they all interact with C3b and C4b during activation of the cascade. The repeating units also occur in the functionally unrelated proteins subcomponent C lr,~ 2-glycoprotein I, blood clotting factor XIII and interleukin-2 receptor. In this review Ken Reid and his colleagues propose that this could be a general feature of a superfamily of structurally related proteins.The complement system is composed of at least 20 plasma glycoproteins. This number includes seven control proteins in addition to the 13 components of the classical and alternative pathways which are the well characterized routes by which activation of the system takes place 1-3 (Fig. 1). Many of the biological effects of the complement system (which can involve the induction of inflammatory responses, engulfment, killing and lysis of bacteria and viruses) are mediated by a variety of cellular receptors 4 such as the C3blC4b receptor (CRI) which can bind to the activated components (principally C3blC4b) or the fragments generated on limited proteolysis of these activated components by the action of control proteins such as the enzyme factor I and its cofactors factor H (H), CRI and C4b-binding protein (C4BP). A feature of these three groups of proteins associated with the complement system, ie compone_nts, control proteins and receptors, is the presence in each group of two, or more, proteins which interact with C3b, or C4b (Fig. I). A summary of the biochemistry and genetics of the control proteins C4BP and H, the membrane bound proteins CRI, decay accelerating factor (DAF) and glycoprotein 45-70 (gp 45-70) which pointed out the functional similarity between those proteins, was recently given in Immunology Today by Holers et al. 5. However, an interesting feature which has emerged from detailed structural studies is that, in addition to showing functional homology, the control proteins C4BP and H and the receptor CRI show an unusual type of structural homology that is shared with the components C2, factor B and subcomponent Clr, and at least three
人补体因子 B 酶原的完整一级结构。
DOI：
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发表时间：
1984
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Mole,JE;Anderson,JK;Davison,EA;Woods,DE
通讯作者：
Woods,DE
人补体蛋白 H 的结构分析：与 C4b 结合蛋白、β 2-糖蛋白 I 和 B2 的 Ba 片段同源。
DOI：
--
发表时间：
1986
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Kristensen,T;Wetsel,RA;Tack,BF
通讯作者：
Tack,BF