Regulated Production of CXCL13 within the Central Nervous System.
Regulated Production of CXCL13 within the Central Nervous System.
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DOI：
10.4172/2155-9899.1000460
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发表时间：
2016-10-01
期刊：
影响因子：
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通讯作者：
Irani, David N
中科院分区：
文献类型：
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作者：
Irani, David N
趋化因子 C-X-C 基序配体 13 (CXCL13) 在淋巴器官中组成型表达，并控制这些特殊结构内淋巴细胞和抗原呈递细胞的募集和划分。然而，最近的数据也显示在中枢神经系统（CNS）炎症期间的各种情况下都会诱导这种分子。虽然其在中枢神经系统肿瘤、感染性和自身免疫性疾病发病机制中的作用仍未完全了解，但越来越多的证据表明，CXCL13 至少可以成为其中一些疾病的相关治疗靶点。本综述重点关注已知调节发炎中枢神经系统中 CXCL13 产生的疾病、细胞来源和外部因素。
The chemokine, C-X-C motif ligand 13 (CXCL13), is constitutively expressed in lymphoid organs and controls the recruitment and compartmentalization of lymphocytes and antigen presenting cells within these specialized structures. Recent data, however, also show induction of this molecule under a variety of circumstances during central nervous system (CNS) inflammation. While its role(s) in the pathogenesis of neoplastic, infectious and autoimmune disorders of the CNS remain incompletely understood, growing evidence suggests that CXCL13 could become a relevant therapeutic target in at least some of these conditions. This review focuses on the diseases, cellular sources and external factors known to regulate CXCL13 production in the inflamed CNS.