A cluster of meningococcal disease in western Sydney, Australia initially associated with a nightclub
A cluster of meningococcal disease in western Sydney, Australia initially associated with a nightclub
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澳大利亚悉尼西部的一组脑膜炎球菌病最初与一家夜总会有关
作者：
J. Jelfs;B. Jalaludin;Robert Munro;M. Patel;M. Kerr;D. Daley;S. Neville;A. Capon
1996 年 8 月至 9 月，澳大利亚悉尼西部发生了 14 例脑膜炎球菌病 (MD) 病例。受影响的 10 名年轻人中有 7 人与当地一家夜总会有直接或间接的联系。 11 种系统性脑膜炎球菌分离株中有 10 种具有表型 C[ratio]2a[ratio]P1.5，并且通过脉冲场凝胶电泳 (PFGE) 显示出密切的遗传关系。这种表型的生物体以前没有在澳大利亚引起过疫情，但与欧洲、加拿大和美国的疫情和高流行血清群 C MD 有关。这是澳大利亚城市报告的最大的 C MD 血清群聚集性事件，也是第一个涉及夜总会的聚集性聚集性事件。菌株分化结果的速度足够快，足以加强日常的流行病学调查。因此，公共卫生工作人员可以快速建立病例之间的联系，跟踪社区中新病例的传播，向卫生官员和媒体提供准确的信息，并利用有关该表型特征的现有知识来预测疫情爆发期间及之后可能的发展。当考虑疫苗接种的作用时，菌株分化数据也非常有帮助，并且现有的管理MD爆发的指南可以在悉尼西部首次得到有效使用。
Fourteen cases of meningococcal disease (MD) occurred in August–September 1996 in western Sydney, Australia. Seven of the 10 young adults affected had a direct or indirect link with a local nightclub. Ten of 11 systemic meningococcal isolates had the phenotype C[ratio ]2a[ratio ]P1.5 and showed close genetic relationship by pulsed-fleld gel electrophoresis (PFGE). Organisms of this phenotype have not previously caused outbreaks in Australia, but have been associated with outbreaks and hyperendemic serogroup C MD in Europe, Canada, and the United States. This is the largest cluster of serogroup C MD reported in urban Australia, and the first involving a nightclub. The strain differentiation results were available rapidly enough to augment epidemiological investigations on a daily basis. Public health staff could thus establish links between cases quickly, follow the spread of new cases in the community, give accurate information to health officials and the press, and utilize existing knowledge about the characteristics of this phenotype to predict likely developments during the outbreak and afterwards. The strain differentiation data was also very helpful when the role of vaccination was considered, and existing guidelines on the management of outbreaks of MD could be used effectively for the first time in western Sydney.
大 DNA 分子的纯化、特异性片段化和分离。
影响因子：
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作者：
Smith,CL;Cantor,CR
通讯作者：
Cantor,CR