Spectral optical coherence tomography - A novel technique for cornea imaging
Spectral optical coherence tomography - A novel technique for cornea imaging
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DOI：
10.1097/01.ico.0000224644.81719.59
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发表时间：
2006-09-01
期刊：
影响因子：
2.8
通讯作者：
Targowski, Piotr
中科院分区：
文献类型：
--
作者：
Kaluzny, Bartlomiej J.;Kaluzny, Jakub J.;Targowski, Piotr
目的：光谱光学相干层析成像（SOCT）是一种新的，非侵入性，非接触，高分辨率的技术，提供了横截面图像的对象，弱吸收和散射光。SOCT由于其采集时间短、灵敏度高，能够提供比传统OCT质量更好的断层图像。本文的目的是展示SOCT在角膜及其病变的横截面成像中的应用。用裂隙灯检查了11只具有不同角膜病理的眼睛，并使用了由美国国家科学院研究所制造的SOCT原型仪器。结果：我们的SOCT系统提供高分辨率（4 μ m轴向，10 μ m横向）断层图像，由3000-5000 A扫描组成，采集时间为120-200 ms。图像的质量足以对各种角膜病变进行详细的横截面评估。可以客观评估变化组织的定位、大小、形状和光散射特性。角膜和上皮厚度和深度和宽度的病变可以estimated.Conclusion：SOCT技术可以获得具有临床价值的横截面光学活检的角膜及其病理。
Purpose: Spectral optical coherence tomography (SOCT) is a new, noninvasive, noncontact, high-resolution technique that provides cross-sectional images of the objects that weakly absorb and scatter light. SOCT, because of very short acquisition time and high sensitivity, is capable of providing tomograms of substantially better quality than the conventional OCT. The aim of this paper is to show the application of the SOCT to cross-sectional imaging of the cornea and its pathologies.Methods: Eleven eyes with different corneal pathologies were examined with a slit lamp and the use of a prototype SOCT instrument constructed in the Institute of Physics, Nicolaus Copernicus University, Torun, Poland.Results: Our SOCT system provides high-resolution (4 mu m axial, 10 mu m transversal) tomograms composed of 3000-5000 A-scans with an acquisition time of 120-200 ms. The quality of the images is adequate for detailed cross-sectional evaluation of various corneal pathologies. Objective assessment of the localization, size, shape, and light-scattering properties of the changed tissue is possible. Corneal and epithelial thickness and the depth and width of lesions can be estimated.Conclusion: SOCT technique allows acquiring clinically valuable cross-sectional optical biopsy of the cornea and its pathologies.