EFFECTS OF POSTNATAL STRESS ON DOPAMINE MESOLIMBIC SYSTEM RESPONSES TO AVERSIVE EXPERIENCES IN ADULT LIFE
EFFECTS OF POSTNATAL STRESS ON DOPAMINE MESOLIMBIC SYSTEM RESPONSES TO AVERSIVE EXPERIENCES IN ADULT LIFE
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DOI：
10.1016/0006-8993(93)90374-v
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发表时间：
1993-02-26
期刊：
影响因子：
2.9
通讯作者：
DAMATO, FR
中科院分区：
文献类型：
--
作者：
CABIB, S;PUGLISIALLEGRA, S;DAMATO, FR
研究了产后应激对90日龄小鼠中脑边缘多巴胺（DA）功能的影响。产后压力包括在出生后的前两周，在母亲不在的情况下，每天15分钟暴露在清洁床上（CB）。对照组在母亲不在场的情况下，每天接触家用笼床（HCB）。短暂（5-10分钟）暴露于抑制条件下，成年HCB伏隔核（NAS）中DA代谢物（3,4-二羟基苯乙酸（DOPAC）、同型香草酸（HVA）和3-甲氧基酪胺（3- mt））明显增加，但CB小鼠没有。此外，在高架迷宫中，与HCB小鼠相比，CB小鼠表现出更多的探索和更少的恐惧。综上所述，这些结果表明，成年小鼠在出生后的发育过程中反复受到压力，情绪反应会降低。此外，HCB小鼠而非CB小鼠在成年生活中重复约束应激（每天10次120分钟）后对阿啡啡的行为反应发生了改变，尽管在CB组和HCB组的成年无应激小鼠中，对低剂量和高剂量阿啡啡的行为反应没有差异。这些结果表明，早期经历对大脑DA功能的影响可能在基础条件下并不明显，只有在环境压力下才会显现出来。最后，单次暴露于120分钟的限制对成年HCB和CB小鼠NAS中的DA代谢（3-MT减少，DOPAC和HVA水平增加）有相似的影响，这表明出生后应激经历不会影响中边缘DA系统对不可避免的厌恶经历的反应能力。
The effects of postnatal stress on mesolimbic dopamine (DA) functioning in 90-day-old mice were investigated. Postnatal stress consisted of 15 min daily exposure to clean bedding (CB) in the absence of the mother for the first two weeks of life. Controls were daily exposed to home cage bedding (HCB) in the absence of the mother. A single brief (5-10 min) exposure to restraint produced a clear-cut increase in DA metabolites (3,4-dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA) and 3-methoxytyramine (3-MT)) in the nucleus accumbens septi (NAS) of adult HCB but not CB mice. Moreover, when tested in an elevated plus maze, CB mice showed more exploration and reduced fearfulness in comparison with HCB mice. Taken together, these results indicate reduced emotional reactivity in adult mice repeatedly stressed during postnatal development. Moreover, HCB mice but not CB mice showed altered behavioral responsiveness to apomorphine following repeated restraint stress (10 daily 120 min) in adult life, although no difference in the behavioral response to either a low or a high dose of apomorphine was observed in adult unstressed mice of the CB and HCB groups. These results indicate that the effects of early experiences on brain DA functioning may not be evident in basal conditions and be revealed only under environmental pressure. Finally, a single exposure to 120 min of restraint had similar effects on DA metabolism (decrease of 3-MT and increase of DOPAC and HVA levels) in the NAS of adult HCB and CB mice, suggesting that postnatal stress experiences do not affect the ability of the mesolimbic DA system to respond to unavoidable aversive experiences.