The application of 595-nm pulsed dye laser for vascular anomalies in a Chinese population: a 10-year experience
The application of 595-nm pulsed dye laser for vascular anomalies in a Chinese population: a 10-year experience
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595纳米脉冲染料激光在中国人群血管异常治疗中的应用：10年经验
DOI：
10.1080/14764172.2018.1502450
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发表时间：
2018
影响因子：
1.2
通讯作者：
Yu
中科院分区：
文献类型：
--
作者：
M. Lin;Chrang;Sindy Hu;J. Chang;W. Chung;Zhi;Sheng;Yu
摘要背景：595 nm 脉冲染料激光 (PDL) 用于治疗血管异常已有约 30 年的历史；然而，关于中国患者的治疗效果、优化参数和手术技术的数据不足。目的：研究PDL治疗中国血管异常患者的疗效及相关因素。方法：在这项回顾性研究中，我们招募了 431 名患有 8 种不同血管异常且既往未接受过治疗的患者。研究了血管异常的详细分类以及 PDL 的各种参数和技术。使用研究者总体评估来分析临床结果。结果：改善与婴儿血管瘤 (IH) 亚型显着相关 (p < 0.05)。疗效与病变颜色、解剖部位和肥厚型鲜红斑痣 (PWS) 之间存在显着相关性 (p < 0.05)。疗效与年龄或性别之间没有显着相关性（p > 0.05）。结论：PDL 是治疗中国患者血管异常的一种有效且安全的治疗方式。我们确定，在治疗前区分和识别 IH 亚型可能是预测治疗结果的有用参数。 PWS 的病变颜色、部位和肥厚性变化是相关的治疗因素。 PDL 参数和技术根据各种血管异常而有所不同，以达到最佳结果。
ABSTRACT Background: The 595-nm pulsed dye laser (PDL) has been used to treat vascular anomalies for about 30 years; however, there are insufficient data in Chinese patients concerning therapeutic efficacy, optimized parameters, and procedure techniques. Objective: To study the efficacy and relevant factors in PDL therapy for vascular anomalies in Chinese patients. Method: We enrolled 431 patients with 8 different vascular anomalies and no previous treatment in this retrospective study. A detailed classification of vascular anomalies and various parameters and techniques of PDL were studied. The clinical outcomes were analysed using the Investigator Global Assessment. Results: Improvements were significantly correlated with infantile haemangioma (IH) subtypes (p < 0.05). A significant correlation between efficacy and lesion colour, anatomical sites, and hypertrophic-type port-wine stain (PWS) was found (p < 0.05). There was no significant correlation between efficacy and age or sex (p > 0.05). Conclusion: PDL is an effective and safe therapeutic modality for managing vascular anomalies in Chinese patients. We determined that differentiating and identifying IH subtypes prior to treatment could be a useful parameter for predicting therapeutic results. Lesion colour, sites, and hypertrophic changes in PWS are relevant therapeutic factors. PDL parameters and techniques differ according to the various vascular anomalies to achieve optimal results.