Myosin-V motility: these levers were made for walking.
Myosin-V motility: these levers were made for walking.
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DOI：
10.1016/s0962-8924(03)00172-7
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发表时间：
2003-09
影响因子：
19
通讯作者：
M. Tyska;M. Mooseker
中科院分区：
文献类型：
--
作者：
M. Tyska;M. Mooseker
肌球蛋白-Va，一种被认为参与细胞器运输的基于肌动蛋白的进行性马达，现在准备加入肌球蛋白-II（来自肌肉），成为肌球蛋白超家族中最具特征的成员之一。戈德曼和他的同事们以及塞尔文和他的同事们的实验室最近的报告提供了前所未有的高分辨率视图，显示了这个马达沿着轨道运动时发生的结构变化。总之，新的结果表明，肌球蛋白Va倾斜其轻链结合域“走”沿沿着肌动蛋白在一个手在手的方式。
Myosin-Va, a processive actin-based motor thought to be involved in organelle transport, now stands ready to join myosin-II (from muscle) as one of the most highly characterized members of the myosin superfamily. Recent reports from the laboratories of Goldman and colleagues and Selvin and colleagues have provided unprecedented, high-resolution views of the structural changes that take place while this motor moves along its track. Taken together, the new results indicate that myosin-Va tilts its light chain binding domains to ‘walk' along actin in a hand-over-hand fashion.