Physiological variation in estradiol and brain function: A functional magnetic resonance imaging study of verbal memory across the follicular phase of the menstrual cycle
Physiological variation in estradiol and brain function: A functional magnetic resonance imaging study of verbal memory across the follicular phase of the menstrual cycle
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DOI：
10.1016/j.yhbeh.2007.11.005
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发表时间：
2008-04-01
影响因子：
3.5
通讯作者：
Murphy, Declan G. M.
中科院分区：
文献类型：
--
作者：
Craig, Michael C.;Fletcher, Paul C.;Murphy, Declan G. M.
女性在其生殖生活中某些与雌激素浓度变化相关的时期（例如更年期前后和分娩前后）经常抱怨记忆力问题。此外，行为研究表明，记忆力表现可能会在月经周期中波动。例如，据报道在与高雌激素浓度相关的阶段，语言任务的表现最佳，而在视觉空间任务方面则情况相反。这些所报道的效应的生物学基础仍知之甚少。然而，对绝经后女性雌激素治疗效果的脑成像研究表明，雌激素调节着对记忆起作用的脑区的代谢和功能。此外，我们最近报道，年轻女性卵巢功能的急性抑制（使用促性腺激素释放激素激动剂）与在成功的语言记忆编码过程中左侧前额叶皮质，特别是左侧额下回（LIFG）的激活降低有关。因此，我们研究了血浆雌二醇浓度的生理变化是否与成功的语言编码过程中LIFG的活动差异有关。我们假设血浆中较高的雌二醇浓度将与LIFG的大脑活动增加以及回忆表现的改善相关。尽管我们没有发现血浆雌二醇浓度与语言回忆表现之间存在显著关系，但我们报告了在LtFG处大脑功能与雌二醇浓度之间存在正相关。（c）2008年由爱思唯尔公司出版
Women frequently complain of memory problems at times in their reproductive lives that are associated with changes in estrogen concentration (e.g. around menopause and childbirth). Further, behavioural studies suggest that memory performance may fluctuate across the menstrual cycle. For example, performance on verbal tasks has been reported to be greatest during phases associated with high estrogen concentrations whereas the opposite has been reported with visuo-spatial tasks. The biological basis of these reported effects remains poorly understood. However, brain imaging studies into the effects of estrogen therapy in postmenopausal women suggest that estrogen modulates the metabolism and function of brain regions sub-serving memory. Furthermore, we have recently reported that acute suppression of ovarian function in young women (with a Gonadotropin Hormone Releasing Hormone agonist) is associated with decreased activation in left prefrontal cortex, particularly the left inferior frontal gyrus (LIFG), during successful verbal memory encoding. We therefore investigated whether pbysiological variation in plasma estradiol concentration is associated with differences in activity of the LIFG during successful verbal encoding. We hypothesised that higher plasma concentrations of estradiol would be associated with increased brain activity at the LIFG and improved recall performance. Although we did not find a significant relationship between plasma estradiol concentration and verbal recall performance, we report a positive correlation between brain function and estradiol concentration at the LtFG. (c) 2008 Published by Elsevier Inc.