Comparison of outcomes of unrelated bone marrow and umbilical cord blood transplants in children with acute leukemia
Comparison of outcomes of unrelated bone marrow and umbilical cord blood transplants in children with acute leukemia
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DOI：
10.1182/blood.v97.10.2962
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发表时间：
2001-05-15
期刊：
影响因子：
20.3
通讯作者：
Gluckman, E
中科院分区：
文献类型：
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作者：
Rocha, V;Cornish, J;Gluckman, E
为了比较非亲缘脐带血移植（UCBTs）或骨髓移植的结果，在一项回顾性多中心研究中分析了541例接受脐带血（n = 99）、T细胞去除非亲缘骨髓移植（T-UBMT）（n = 180）或非操作（UBMT）（n = 262）移植的急性白血病（AL）儿童。在调整患者、疾病和移植变量后进行比较。3组之间的主要差异是UCBT组中HLA错配的数量更高（通过I类血清学和DRB 1分子分型定义）。供者HLA不匹配的UCBTs占92%，UBMTs占18%，T-UBMTs占43%（P
In order to compare the outcomes of unrelated umbilical cord blood transplants (UCBTs) or bone marrow transplants, 541 children with acute leukemia (AL) transplanted with umbilical cord blood (n = 99), T-cell-depleted unrelated bone marrow transplants (T-UBMT) (n = 180), or nonmanipulated (UBMT) (n = 262), were analyzed in a retrospective multicenter study. Comparisons were performed after adjustment for patient, disease, and transplant variables. The major difference between the 3 groups was the higher number in the UCBT group of HLA mismatches (defined by serology for class I and molecular typing for DRB1). The donor was HLA mismatched in 92% of UCBTs, in 18% of UBMTs, and in 43% of T-UBMTs (P