The Future of Gene-Guided Neuroscience Research in Non-Traditional Model Organisms
The Future of Gene-Guided Neuroscience Research in Non-Traditional Model Organisms
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DOI：
10.1159/000500072
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发表时间：
2019-01-01
影响因子：
1.7
通讯作者：
Juntti, Scott
中科院分区：
文献类型：
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作者：
Juntti, Scott
动物在形态、功能和行为上的自然变异一直是科学家灵感的来源。尽管如此，专注于行为神经基础的实验学家越来越多地关注少数几个模型物种。这种整合的动机主要是在这些物种的操纵资源和技术的可用性。近年来，主要在传统模式物种中开发的实验方法激增，但原则上可以很容易地应用于任何物种。高通量测序、CRISPR基因编辑、转基因和其他技术通过在非传统模式物种中的部署，实现了新的见解。这种方法的可用性改变了对研究哪些物种的计算，特别是当感兴趣的特征在非传统模式生物中最容易观察到时。如果这些技术在许多新物种中被广泛采用，它有望彻底改变神经行为学领域。(C)2019 S. Karger AG，巴塞尔
Natural variations across animals in form, function, and behavior have long been sources of inspiration to scientists. Despite this, experimentalists focusing on the neural bases of behavior have increasingly focused on a select few model species. This consolidation is motivated primarily by the availability of resources and technologies for manipulation in these species. Recent years have witnessed a proliferation of experimental approaches that were developed primarily in traditional model species, but that may in principle be readily applied to any species. High-throughput sequencing, CRISPR gene editing, transgenesis, and other technologies have enabled new insights through their deployment in non-traditional model species. The availability of such approaches changes the calculation of which species to study, particularly when a trait of interest is most readily observed in a non-traditional model organism. If these technologies are widely adopted in many new species, it promises to revolutionize the field of neuroethology. (C) 2019 S. Karger AG, Basel