Cell plasticity in lung injury and repair: report from an NHLBI workshop, April 19-20, 2010.
Cell plasticity in lung injury and repair: report from an NHLBI workshop, April 19-20, 2010.
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DOI：
10.1513/pats.201012-067cb
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发表时间：
2011-06-01
期刊：
影响因子：
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通讯作者：
Hoshizaki, Deborah
中科院分区：
文献类型：
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作者：
Borok, Zea;Whitsett, Jeffrey A;Hoshizaki, Deborah
2010年4月，NIH召开了一次研讨会，讨论了对肺细胞可塑性的理解现状，包括上皮细胞对损伤的反应，目的是总结已知的，该领域需要知道的以及如何到达那里。本研讨会的近端刺激是最近的证据表明，可塑性是肺上皮细胞的一个突出的，但不完全特征的属性，特别是对上皮细胞生物学这方面的理解，可能是一个重要的窗口疾病的病理生物学和发病机制。除了在维持组织稳态方面的许多重要功能外，上皮细胞已成为疾病起始的中心靶点和疾病进展的积极贡献者，从而及时研究细胞可塑性在肺损伤和修复中的作用。该研讨会围绕四个主要主题组织：肺上皮细胞可塑性，可塑性的信号控制，成纤维细胞可塑性和串扰，以及人类疾病的翻译。虽然这种分类被认为有些人为，但人们认为，这种办法将促进通常不进行交流的群体之间的交流，并有助于产生新的办法。以下是各小组讨论的简要报告，随后是讲习班与会者的共识优先事项和建议。
In April 2010, a NIH workshop was convened to discuss the current state of understanding of lung cell plasticity, including the responses of epithelial cells to injury, with the objectives of summarizing what is known, what the field needs to know, and how to get there. The proximal stimulus for this workshop is the body of recent evidence suggesting that plasticity is a prominent but incompletely characterized property of lung epithelial cells, and that a focus on understanding this aspect of epithelial cell biology in particular, may be an important window into disease pathobiology and pathogenesis. In addition to their many vital functions in maintaining tissue homeostasis, epithelial cells have emerged as both a central target of disease initiation and an active contributor to disease progression, making a workshop to investigate the role of cell plasticity in lung injury and repair timely. The workshop was organized around four major themes: lung epithelial cell plasticity, signaling control of plasticity, fibroblast plasticity and crosstalk, and translation to human disease. Although this breakdown was recognized to be somewhat artificial, it was felt that this approach would promote cross-fertilization among groups that ordinarily do not communicate and lend itself to the generation of new approaches. The summary reports of individual group discussions below are followed by consensus priorities and recommendations of the workshop participants.