Otlx2, an Otx-related homeobox gene expressed in the pituitary gland and in a restricted pattern in the forebrain
Otlx2, an Otx-related homeobox gene expressed in the pituitary gland and in a restricted pattern in the forebrain
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DOI：
10.1006/mcne.1996.0062
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发表时间：
1996-01-01
影响因子：
3.5
通讯作者：
Brunet, JF
中科院分区：
文献类型：
--
作者：
Mucchielli, ML;Martinez, S;Brunet, JF
脊椎动物的神经系统是由神经上皮区域和细胞群相继特化而形成的。提出的主要组织发生步骤之一是神经管沿其尾嘴侧和背腹侧轴沿着细分为隔室。这一事件是反映，并可能是直接的，由许多转录因子的表达限制。在这里，我们报告一个新的同源异型盒基因的配对的超类，Otlx 2，其早期的表达模式在中脑和前脑的分离是一致的脑形态与建议的神经模型。此外，其晚期胚胎和出生后的表达，在明确的连续性与早期的模式，表明在神经元分化和组织发生的几个前脑和中脑领域的作用。最后，Otlx 2从Rathke囊（腺垂体的原基）中最早的形态发生事件开始表达，该表达位点由非常接近的同源物Otlx 1/Ptx 1/P-Otx共享。
The vertebrate nervous system forms by the specification of, successively, neuroepithelial regions and cell groups. One of the proposed major histogenetic steps is the subdivision of the neural tube in compartments along its caudorostral and dorsoventral axis. This event is reflected, and may be directed, by the restricted expression of many transcription factors. Here, we report on the isolation of a new homeobox gene of the paired superclass, Otlx2, whose early expression pattern in the mesencephalon and prosencephalon is congruent with proposed neuromeric models of brain morphogenesis. In addition, its late embryonic and postnatal expression, in clear continuity with the earlier pattern, suggests a role in the neuronal differentiation and the histogenesis of several prosencephalic and mesencephalic areas. Finally, Otlx2 is expressed from the earliest morphogenetic events in the Rathke's pouch, the anlage of the adenohypophysis, an expression site shared by a very close homologue, Otlx1/Ptx1/P-Otx.