The unrecognized potential of pet cats for studying aging and age-related diseases.
The unrecognized potential of pet cats for studying aging and age-related diseases.
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DOI：
10.31491/apt.2021.12.069
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发表时间：
2021-12-31
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影响因子：
--
通讯作者：
Ladiges W
中科院分区：
文献类型：
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作者：
Ladiges W
老猫会患上与老年人相似的慢性病。四分之一的美国家庭养猫，几乎一半的猫超过7岁。猫咪们生活在同一个环境中，也面临着许多相同的化学压力。此外，基因组多样性和种群分层与人类相似。有了这些比较特征，衰老猫代表了一个老年科学模型来研究衰老的发病机制和治疗干预措施。然而，猫通常不被认为是衰老研究的转化模型，主要是因为科学界缺乏知识和欣赏。此外，猫的主人不知道任何旨在促进宠物健康衰老的研究项目，因为根本不存在。我们需要做很多工作来告知和教育科学界以及猫的主人，老龄猫作为一种变革模式的力量，可以研究衰老和与年龄相关的疾病，这将有利于人类和猫的健康。
Old cats develop chronic diseases similar to diseases in older people. One-fourth of American households own cats, and almost half are more than 7 years old. Cats share the same environment and are exposed to many of the same chemical stresses. In addition, genomic diversity and population stratification are similar to that occurring in people. With these comparative features, the aging cat represents a geroscience model to investigate the pathogenesis and therapeutic interventions for aging. However, cats are generally not recognized as a translational model for aging research mainly because of the lack of knowledge and appreciation within the scientific community. In addition, cat owners are not aware of any research programs designed to enhance healthy aging in their pets because none exist. Much work is needed to inform and educate the scientific community as well as cat owners about the power of aging cats as a transformative model to investigate aging and age-related diseases that will benefit both human and feline health.