Trapping rhodium vinylcarbenoids with aminochalcones for the synthesis of medium-sized azacycles
Trapping rhodium vinylcarbenoids with aminochalcones for the synthesis of medium-sized azacycles
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DOI：
10.1016/j.tetlet.2019.151253
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发表时间：
2019-11-14
影响因子：
1.8
通讯作者：
Sharma, Indrajeet
中科院分区：
文献类型：
--
作者：
Chinthapally, Kiran;Massaro, Nicholas P.;Sharma, Indrajeet
本文报道了铑卡宾引发的级联反应，用于中等大小氮杂环化合物的立体选择性合成。级联方法利用容易获得的N-苄基保护的氨基查耳酮和乙烯基重氮化合物通过卡宾-氮插入/羟醛/氧代Cope序列获得9元氮杂环。级联反应已被证明与一系列的N-苄基保护的氨基查耳酮和乙烯基重氮化合物，以提供不同的中等大小的氮杂环。(C)2019爱思唯尔有限公司版权所有。
A rhodium carbenoid initiated cascade has been developed for the stereoselective synthesis of medium-sized azacycles. The cascade approach utilizes readily accessible N-benzyl protected aminochalcones and vinyldiazo compounds to access 9-membered azacycles through a carbene- nitrogen insertion/aldol/oxyCope sequence. The cascade reaction has proven general with a range of N-benzyl protected aminochalcones and vinyldiazos to provide diverse medium-sized azacycles. (C) 2019 Elsevier Ltd. All rights reserved.