A multimodality vascular imaging phantom of an abdominal aortic aneurysm with a visible thrombus
A multimodality vascular imaging phantom of an abdominal aortic aneurysm with a visible thrombus
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DOI：
10.1118/1.4803497
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发表时间：
2013-06-01
期刊：
影响因子：
3.8
通讯作者：
Cloutier, Guy
中科院分区：
文献类型：
--
作者：
Allard, Louise;Soulez, Gilles;Cloutier, Guy
目的：随着新型覆膜支架和植入技术的不断发展，使用标准、开孔型或分支覆膜支架进行腔内修复术治疗解剖结构具有挑战性的腹主动脉瘤（AAA）在技术上已变得可行。体外实验对于改进覆膜支架的设计和顺应性，或为覆膜支架输送或随访提供影像学指导非常有用。血管复制品还有助于更好地了解血管内方法在挑战性解剖结构中的局限性，并可能通过在实验室中实施高风险临床手术来改善手术计划或培训，以改善手术室的结局。大多数可用的AAA体模具有非常基本的解剖结构，不能代表临床现实。本文提出了一种方法，一个现实的AAA幻影与可见的血栓，以及一些机械性能表征这样的phantom.Methods：一个现实的AAA几何复制品的真实的患者解剖结构取自多探测器计算机断层扫描（CT）扫描制造。为了证明这种新体模的多模态成像能力，在磁共振（MR）血管造影、CT血管造影（CTA）、数字减影血管造影（DSA）和超声中可见血栓，使用标准临床方案进行所有这些模态的图像采集。还测试了该体模用于支架展开的可能性。流变仪允许定义hyperelastic和粘弹性的幻影materials.Results：MR成像测量的SNR和CNR值的T1和T2加权序列和MR血管造影表明合理的协议与公布的值AAA血栓和腹部组件在体内。X线吸收也在AAA患者的正常范围内，代表了CTA、荧光透视和DSA观察到的结果。超声传播速度发达的材料也与文献血管和腹部tissues.Conclusions一致：模仿腹部组织，AAA壁，周围血栓的开发，以匹配在体内MR，CT和超声检查的成像特征。该体模对于AAA血管内修复术的血管内器械的图像校准、分割和测试应具有价值。(C)2013年美国医学物理学家协会。
Purpose: With the continuous development of new stent grafts and implantation techniques, it has now become technically feasible to treat abdominal aortic aneurysms (AAA) with challenging anatomy using endovascular repair with standard, fenestrated, or branched stent-grafts. In vitro experimentations are very useful to improve stent-graft design and conformability or imaging guidance for stent-graft delivery or follow-up. Vascular replicas also help to better understand the limitation of endovascular approaches in challenging anatomy and possibly improve surgical planning or training by practicing high risk clinical procedures in the laboratory to improve outcomes in the operating room. Most AAA phantoms available have a very basic anatomy, which is not representative of the clinical reality. This paper presents a method of fabrication of a realistic AAA phantom with a visible thrombus, as well as some mechanical properties characterizing such phantom.Methods: A realistic AAA geometry replica of a real patient anatomy taken from a multidetector computed tomography (CT) scan was manufactured. To demonstrate the multimodality imaging capability of this new phantom with a thrombus visible in magnetic resonance (MR) angiography, CT angiography (CTA), digital subtraction angiography (DSA), and ultrasound, image acquisitions with all these modalities were performed by using standard clinical protocols. Potential use of this phantom for stent deployment was also tested. A rheometer allowed defining hyperelastic and viscoelastic properties of phantom materials.Results: MR imaging measurements of SNR and CNR values on T1 and T2-weighted sequences and MR angiography indicated reasonable agreement with published values of AAA thrombus and abdominal components in vivo. X-ray absorption also lay within normal ranges of AAA patients and was representative of findings observed on CTA, fluoroscopy, and DSA. Ultrasound propagation speeds for developed materials were also in concordance with the literature for vascular and abdominal tissues.Conclusions: The mimicked abdominal tissues, AAA wall, and surrounding thrombus were developed to match imaging features of in vivo MR, CT, and ultrasound examinations. This phantom should be of value for image calibration, segmentation, and testing of endovascular devices for AAA endovascular repair. (C) 2013 American Association of Physicists in Medicine.