CRYSTAL-STRUCTURE OF A HYDRATED GRAMICIDIN S UREA COMPLEX
CRYSTAL-STRUCTURE OF A HYDRATED GRAMICIDIN S UREA COMPLEX
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DOI：
10.1038/275206a0
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发表时间：
1978-01-01
期刊：
影响因子：
64.8
通讯作者：
DODSON, EJ
中科院分区：
文献类型：
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作者：
HULL, SE;KARLSSON, R;DODSON, EJ
环十肽抗生素短杆菌肽S的序列为：自从Gause和Brazhenova分离出短杆菌肽1以来，几位作者提出了可能的构象2 -10。在这些模型中，获得最普遍接受的是Hodgkin和Oughton 2的模型，他们提出结构由两个由脯氨酸残基连接的β链组成，并由四个分子内氢键稳定。短杆菌肽S的几种衍生物已经结晶8，11，但它还没有可能解决任何结构12。我们现在报告短杆菌肽S-尿素复合物的结构，其中短杆菌肽分子的构象有点扭曲的霍奇金-奥顿模型。
THE cyclic decapeptide antibiotic gramicidin S has the sequence Since its isolation by Gause and Brazhnikova1, several authors have proposed possible conformations2–10. Of these models, the one that has gained most general acceptance is that of Hodgkin and Oughton2, who proposed that the structure consisted of two β-chains linked by proline residues and stabilised by four intramolecular hydrogen bonds. Several derivatives of gramicidin S have been crystallised8, 11, but it had not been possible to solve any of the structures12. We now report the structure of a gramicidin S–urea complex in which the gramicidin molecule has a conformation somewhat distorted from the Hodgkin–Oughton model.