The roles of miRNAs as potential biomarkers in lung diseases.
The roles of miRNAs as potential biomarkers in lung diseases.
复制标题
miRNA作为肺部疾病中潜在生物标志物的作用。
DOI：
10.1016/j.ejphar.2016.09.015
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发表时间：
2016-11-15
影响因子：
5
通讯作者：
Velayati A
中科院分区：
文献类型：
--
作者：
Alipoor SD;Adcock IM;Garssen J;Mortaz E;Varahram M;Mirsaeidi M;Velayati A
MicroRNAs （miRNAs）是一种小的非编码rna，可以作为基因表达的主要调控因子，调节几乎所有的生物过程，对维持细胞稳态至关重要。miRNA表达的失调与基因表达异常有关，并可能导致病理状况。有证据表明，miRNA表达谱在健康和疾病之间发生改变，因此可能被视为疾病的生物标志物。越来越多的证据表明，mirna在肺稳态和发育中尤为重要，并已被证明参与许多肺部疾病，如哮喘、慢性阻塞性肺病、结节病、肺癌和其他吸烟相关疾病。更好地了解miRNA的功能及其在肺中的作用机制，将有助于改善当前肺部疾病的诊断和治疗策略。最近，一些基于mirna的药物被引入作为可能的治疗药物。在这篇综述中，我们旨在总结关于mirna在气道和肺中的作用的最新发现，并强调它们在肺部疾病中的潜在治疗作用。
MicroRNAs (miRNAs) are small non-coding RNAs which can act as master regulators of gene expression, modulate almost all biological process and are essential for maintaining cellular homeostasis. Dysregulation of miRNA expression has been associated with aberrant gene expression and may lead to pathological conditions. Evidence suggests that miRNA expression profiles are altered between health and disease and as such may be considered as biomarkers of disease. Evidence is increasing that miRNAs are particularly important in lung homeostasis and development and have been demonstrated to be the involved in many pulmonary diseases such as asthma, COPD, sarcoidosis, lung cancer and other smoking related diseases. Better understanding of the function of miRNA and the mechanisms underlying their action in the lung, would help to improve current diagnosis and therapeutics strategies in pulmonary diseases. Recently, some miRNA-based drugs have been introduced as possible therapeutic agents. In this review we aim to summarize the recent findings regarding the role of miRNAs in the airways and lung and emphasise their potential therapeutic roles in pulmonary diseases.
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DOI：
10.1261/rna.044149.113
发表时间：
2014-09
期刊：
RNA (New York, N.Y.)
影响因子：
--
作者：
Cornett AL;Lutz CS
通讯作者：
Lutz CS
影响因子：
2.6
作者：
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通讯作者：
Gurwitz, Jerry H.
影响因子：
15.9
作者：
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通讯作者：
Semenkovich, Clay F.
DOI：
10.1016/j.ejpb.2009.03.001
发表时间：
2009-08-01
影响因子：
4.9
作者：
Balakrishnan, Prabagar;Lee, Beom-Jin;Choi, Han-Gon
通讯作者：
Choi, Han-Gon
DOI：
10.1016/j.bbrc.2009.07.143
发表时间：
2009-10-23
影响因子：
3.1
作者：
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通讯作者：
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