A STUDY OF THE SERO-IMMUNITY THAT HAS PROTECTED THE SWEDISH POPULATION AGAINST POLIOMYELITIS FOR 25 YEARS
A STUDY OF THE SERO-IMMUNITY THAT HAS PROTECTED THE SWEDISH POPULATION AGAINST POLIOMYELITIS FOR 25 YEARS
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DOI：
10.3109/00365548709117192
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发表时间：
1987-01-01
影响因子：
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通讯作者：
BOTTIGER, M
中科院分区：
文献类型：
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作者：
BOTTIGER, M
尽管由于自然免疫力低下，该人群极易感染脊髓灰质炎，但普遍接种灭活脊髓灰质炎疫苗后，瑞典在6年内（1957-62年）消除了脊髓灰质炎。尽管病毒引入带来的挑战不断发生，但这种状态在 25 年后仍然存在。据估计，超过 99% 的 40 岁及以后出生的人口以及至少 90% 的 40 岁以上出生的人口都接种了疫苗。脊髓灰质炎疫苗接种者的平均抗体水平范围为 100（3 型）和 500（1 型）至 800（2 型）。血清反应呈阴性的人只占一小部分。对免疫持续时间的评估表明，在免疫后2-5年内发生疫苗后滴度下降后，免疫水平保持相当稳定或下降非常缓慢。来自 12 岁瑞典疫苗接种者的血清对用于疫苗生产的 3 型 Saukett 菌株的中和效果比用于疫苗生产的 3 型菌株好 5 倍，比 1984 年芬兰疫情期间分离的 3 型菌株好 5 倍。
Although the population was highly susceptible to poliomyelitis on account of its low natural immunity, the general vaccination with inactivated polio vaccine eliminated poliomyelitis in Sweden within 6 years (1957-62). This status remains after 25 years, although challenges from the introduction of virus occur constantly. Over 99% of the population born in the forties and later is estimated to have been vaccinated, as well as at least 90% of those born earlier. The mean antibody levels of vaccinees against polio range from 100 (type 3) and 500 (type 1) up to 800 (type 2). Seronegative persons are seen only in a small percentage. Evaluation of the duration of immunity indicates that, after the post-vaccination fall in titre which occurs within 2-5 years after immunization, the immune levels remain fairly stable or decline very slowly. Sera from 12-year-old Swedish vaccinees neutralized the type 3 Saukett strain used for vaccine production 5 times better than a type 3 strain used for vaccine production 5 times better than a type 3 strain isolated during the Finnish outbreak 1984.